Enzyme Details

EC Classification

2.3.1.74

Enzyme name
(recommended)

naringenin-chalcone synthase

Alternative names

malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
chalcone synthase
flavanone synthase
6'-deoxychalcone synthase
chalcone synthetase
DOCS
CHS

Classification

Transferases

Acyltransferases

Catalyses reactions

3 Malonyl-CoA + 4-Coumaroyl-CoA <-> 4 Coenzyme A + 3 CO2 + Naringenin chalcone

4-Coumaroyl-CoA <-> Isoliquiritigenin

3 Malonyl-CoA + Cinnamoyl-CoA <-> 4 Coenzyme A + 3 CO2 + (2RS)-4-Arsono-2-hydroxybutanoyl phosphate

3 Malonyl-CoA + Cinnamoyl diketide-NAC <-> 3 Coenzyme A + 3 CO2 + (2RS)-4-Arsono-2-hydroxybutanoyl phosphate + Gossylic nitrile 1,1'-diacetate

3 Malonyl-CoA + Benzyloxycarbonyl-alpha-L-glutamyl(gamma-glycineethylester)glycine <-> 4 CO2 + (2RS)-4-Arsono-2-hydroxybutanoyl phosphate + 3 Cinnamoyl-NAC + Gossylic nitrile 1,1'-diacetate

3 Malonyl-CoA + Cinnamoyl-CoA <-> 4 Coenzyme A + 3 CO2 + 2',4',6'-Trihydroxychalcone

3 Malonyl-CoA + Cinnamoyl-NAC <-> 3 Coenzyme A + 3 CO2 + 2',4',6'-Trihydroxychalcone + N-Acetylcysteamine

3 Malonyl-CoA + Cinnamoyl diketide-NAC <-> 3 Coenzyme A + 4 CO2 + 2',4',6'-Trihydroxychalcone + N-Acetylcysteamine

Malonyl-CoA <-> CO2 + Acetyl-CoA

Coenzyme A + Chalcone synthase <-> Enzyme-Coenzyme A complex

Acetyl-CoA + Chalcone synthase <-> Enzyme-Acetyl-CoA complex

4 Coenzyme A + 3 Malonyl-CoA + 3-Coumaroyl-CoA <-> 3 CO2 + 5,7,3'-Trihydroxyflavanone

3 Malonyl-CoA + 2-Coumaroyl-CoA <-> 4 Coenzyme A + 3 CO2 + 5,7,2'-Trihydroxyflavanone

3 Malonyl-CoA + Phenylpropionyl-CoA <-> 4 Coenzyme A + 3 CO2 + 3-Phenylpropionyl chalcone

3 Malonyl-CoA + 4-Methylcinnamoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + Feruloyl-CoA <-> 4 Coenzyme A + 3 CO2 + Homoeriodictyol chalcone

3 Malonyl-CoA + Phenylacetyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + Benzoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

Acetyl-CoA + 2 Malonyl-CoA <-> 3 Coenzyme A + 2 CO2 + Triacetate lactone

3 Malonyl-CoA + Butanoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + n-Valeryl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + Hexanoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + Heptanoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + Octanoyl-CoA <-> Unknown + 4 Coenzyme A + 3 CO2

3 Malonyl-CoA + N-Methylanthraniloyl-CoA <-> H2O + 4 Coenzyme A + 3 CO2 + N-Methylanthraniloyltriacetic acid lactone

3 Malonyl-CoA + 4-Coumaroyl-CoA <-> 4 Coenzyme A + 3 CO2 + p-Coumaroyltriacetic acid lactone

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.3.1.74