Enzyme Details
EC Classification
2.3.1.85
Enzyme name
(recommended)
fatty-acid synthase
Alternative names
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
yeast fatty acid synthase
Classification
Transferases
Acyltransferases
Acyltransferases
Catalyses reactions
Acetyl-CoA + Holo-[acyl-carrier protein] <-> Coenzyme A + Acetyl-[acyl-carrier protein]
Malonyl-CoA + Holo-[acyl-carrier protein] <-> Coenzyme A + Malonyl-[acyl-carrier protein]
H2O + Hexadecanoyl-[acp] <-> Palmitate + Holo-[acyl-carrier protein]
Malonyl-[acyl-carrier protein] + Acetyl-[acyl-carrier protein] <-> CO2 + Holo-[acyl-carrier protein] + Acetoacetyl-[acp]
NADP+ + (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] <-> H+ + NADPH + Acetoacetyl-[acp]
NADP+ + (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] <-> H+ + NADPH + 3-Oxodecanoyl-[acp]
(3R)-3-Hydroxydecanoyl-[acyl-carrier protein] <-> H2O + trans-Dec-2-enoyl-[acp]
NADP+ + (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <-> H+ + NADPH + 3-Oxooctanoyl-[acp]
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <-> H2O + trans-Oct-2-enoyl-[acp]
NADP+ + (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] <-> H+ + NADPH + 3-Oxohexadecanoyl-[acp]
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] <-> H2O + trans-Hexadec-2-enoyl-[acp]
NADP+ + (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] <-> H+ + NADPH + 3-Oxotetradecanoyl-[acp]
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] <-> H2O + trans-Tetradec-2-enoyl-[acp]
NADP+ + Dodecanoyl-[acyl-carrier protein] <-> H+ + NADPH + trans-Dodec-2-enoyl-[acp]
Malonyl-[acyl-carrier protein] + Dodecanoyl-[acyl-carrier protein] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxotetradecanoyl-[acp]
Malonyl-[acyl-carrier protein] + Butyryl-[acp] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxohexanoyl-[acp]
NADP+ + (R)-3-Hydroxyhexanoyl-[acp] <-> H+ + NADPH + 3-Oxohexanoyl-[acp]
(R)-3-Hydroxyhexanoyl-[acp] <-> H2O + trans-Hex-2-enoyl-[acp]
NADP+ + Hexanoyl-[acp] <-> H+ + NADPH + trans-Hex-2-enoyl-[acp]
Malonyl-[acyl-carrier protein] + Hexanoyl-[acp] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxooctanoyl-[acp]
NADP+ + Octanoyl-[acp] <-> H+ + NADPH + trans-Oct-2-enoyl-[acp]
Malonyl-[acyl-carrier protein] + Octanoyl-[acp] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxodecanoyl-[acp]
NADP+ + Decanoyl-[acp] <-> H+ + NADPH + trans-Dec-2-enoyl-[acp]
Malonyl-[acyl-carrier protein] + Decanoyl-[acp] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxododecanoyl-[acp]
NADP+ + (R)-3-Hydroxydodecanoyl-[acp] <-> H+ + NADPH + 3-Oxododecanoyl-[acp]
(R)-3-Hydroxydodecanoyl-[acp] <-> H2O + trans-Dodec-2-enoyl-[acp]
NADP+ + Tetradecanoyl-[acp] <-> H+ + NADPH + trans-Tetradec-2-enoyl-[acp]
Malonyl-[acyl-carrier protein] + Tetradecanoyl-[acp] <-> CO2 + Holo-[acyl-carrier protein] + 3-Oxohexadecanoyl-[acp]
NADP+ + Hexadecanoyl-[acp] <-> H+ + NADPH + trans-Hexadec-2-enoyl-[acp]
H+ + 2n NADPH + Acetyl-CoA + n Malonyl-CoA <-> 2n NADP+ + n+1 Coenzyme A + n CO2 + Long-chain fatty acid
14 H+ + 14 NADPH + Acetyl-CoA + 7 Malonyl-CoA <-> 14 NADP+ + 8 Coenzyme A + 7 CO2 + Palmitate
H+ + 2n NADPH + n Malonyl-CoA + Butanoyl-CoA <-> 2n NADP+ + n+1 Coenzyme A + n CO2 + Long-chain fatty acid
H+ + 2n NADPH + n Malonyl-CoA + Propanoyl-CoA <-> 2n NADP+ + n+1 Coenzyme A + n CO2 + Long-chain fatty acid
H+ + 2n NADPH + n Malonyl-CoA + Hexanoyl-CoA <-> 2n NADP+ + n+1 Coenzyme A + n CO2 + Long-chain fatty acid
H+ + 2n NADPH + n Malonyl-CoA + Octanoyl-CoA <-> 2n NADP+ + n+1 Coenzyme A + n CO2 + Long-chain fatty acid
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
2.3.1.85
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