Enzyme Details

EC Classification

2.3.3.10

Enzyme name
(recommended)

hydroxymethylglutaryl-CoA synthase

Alternative names

3-hydroxy-3-methylglutaryl coenzyme A synthetase
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
3-hydroxy-3-methylglutaryl CoA synthetase
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-CoA synthase
3-hydroxy-3-methylglutaryl-coenzyme A synthase
beta-hydroxy-beta-methylglutaryl-CoA synthase
HMG-CoA synthase
acetoacetyl coenzyme A transacetase
hydroxymethylglutaryl coenzyme A synthase
hydroxymethylglutaryl coenzyme A-condensing enzyme

Classification

Transferases

Acyltransferases

Acyl groups converted into alkyl on transfer

Catalyses reactions

H2O + Acetyl-CoA <-> Coenzyme A + Acetate

Coenzyme A + 3-Hydroxy-3-methylglutaryl-CoA <-> H2O + Acetyl-CoA + Acetoacetyl-CoA

H2O + Acetyl-CoA + S-(3-Oxobutyl)-CoA <-> Coenzyme A + S-(4-Carboxy-3-hydroxy-isoamyl)-CoA

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.3.3.10