Enzyme Details

EC Classification

2.3.3.13

Enzyme name
(recommended)

2-isopropylmalate synthase

Alternative names

acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
alpha-isopropylmalate synthetase
alpha-isopropylmalate synthase
alpha-isopropylmalic synthetase
isopropylmalate synthase
isopropylmalate synthetase

Classification

Transferases

Acyltransferases

Acyl groups converted into alkyl on transfer

Catalyses reactions

H2O + Acetyl-CoA <-> Coenzyme A + Acetate

Coenzyme A + (R)-2-Ethylmalate <-> H2O + Acetyl-CoA + 2-Oxobutyrate

Coenzyme A + 2-Isopropylmalate <-> H2O + Acetyl-CoA + alpha-Ketovaline

H2O + Propanoyl-CoA <-> Coenzyme A + Propanoate

Pyruvate + H2O + Acetyl-CoA <-> Coenzyme A + D-Citramalate

H2O + Crotonoyl-CoA <-> Coenzyme A + 2-Butenoate

H2O + Acetyl-CoA + 2-Oxopentanoate <-> Coenzyme A + 2-Propylmalate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.3.3.13