Enzyme Details

EC Classification

2.3.3.14

Enzyme name
(recommended)

homocitrate synthase

Alternative names

acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase
homocitrate synthetase
HCS

Classification

Transferases

Acyltransferases

Acyl groups converted into alkyl on transfer

Catalyses reactions

Coenzyme A + Citrate <-> H2O + Acetyl-CoA + Oxaloacetate

Coenzyme A + Homocitrate <-> H2O + Acetyl-CoA + 2-Oxoglutarate

H2O + Acetyl-CoA + 3-Oxoadipate <-> Coenzyme A + 3-Hydroxy-3-carboxymethyl adipic acid

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.3.3.14