Enzyme Details

EC Classification

2.5.1.56

Enzyme name
(recommended)

N-acetylneuraminate synthase

Alternative names

NeuAc synthase
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
(NANA)condensing enzyme
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)

Classification

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Catalyses reactions

Phosphate + N-Acetylneuraminate <-> Phosphoenolpyruvate + H2O + N-Acetyl-D-mannosamine

Phosphate + N-Acetylneuraminate 9-phosphate <-> Phosphoenolpyruvate + H2O + N-Acetyl-D-mannosamine 6-phosphate

Phosphoenolpyruvate + H2O + N-Butanoylmannosamine <-> Phosphate + N-Butanoylneuraminate

Phosphoenolpyruvate + H2O + N-Pentanoylmannosamine <-> Phosphate + N-Pentanoylneuraminate

Phosphoenolpyruvate + H2O + N-Propanoylmannosamine <-> Phosphate + N-Propanoylneuraminate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.5.1.56