Enzyme Details

 EC Classification 2.7.1.21
 Enzyme name
(recommended)		 thymidine kinase
 Alternative names ATP:thymidine 5'-phosphotransferase
thymidine kinase (phosphorylating)
2'-deoxythymidine kinase
deoxythymidine kinase (phosphorylating)
 Classification
Transferases
Transferring phosphorous-containing groups
Phosphotransferases with an alcohol group as acceptor
 Catalyses reactions
ATP + Thymidine <-> ADP + dTMP
ATP + 2'-Deoxycytidine <-> ADP + dCMP
ATP + 2'-Deoxyuridine <-> ADP + dUMP
ATP + Ganciclovir <-> ADP + Ganciclovir phosphate
ATP + Acyclovir <-> ADP + Acyclovir monophosphate
ATP + Zidovudine <-> ADP + 3'-Azido-3'-deoxythymidine 5'-phosphate
Thymidine + dTTP <-> dTMP + TDP
CTP + Thymidine <-> dTMP + CDP
GTP + Thymidine <-> dTMP + GDP
ATP + 1-beta-D-Arabinofuranosylthymine <-> ADP + 1-beta-D-Arabinofuranosylthymine 5'-monophosphate
ATP + 3'-Azido-2',3'-dideoxythymidine <-> ADP + 3'-Azido-2',3'-dideoxythymidine 5'-phosphate
ATP + 3'-Fluoro-2',3'-dideoxythymidine <-> ADP + 3'-Fluoro-2',3'-dideoxythymidine 5'-phosphate
ATP + 5-Fluorodeoxyuridine <-> ADP + 5-Fluorodeoxyuridine 5'-phosphate
CTP + 2'-Deoxycytidine <-> dCMP + CDP
2 Thymidine + VVTK <-> Enzyme-ligand complex
Thymidine + HSV-1 TK <-> Enzyme-ligand complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 2.7.1.21



© HITS gGmbH