Enzyme Details

EC Classification

2.7.1.74

Enzyme name
(recommended)

deoxycytidine kinase

Alternative names

NTP:deoxycytidine 5'-phosphotransferase
deoxycytidine kinase (phosphorylating)
2'-deoxycytidine kinase
Ara-C kinase
arabinofuranosylcytosine kinase
deoxycytidine-cytidine kinase

Classification

Transferases

Transferring phosphorous-containing groups

Phosphotransferases with an alcohol group as acceptor

Catalyses reactions

ATP + Adenosine <-> ADP + AMP

ATP + Deoxyadenosine <-> ADP + dAMP

ATP + Deoxyguanosine <-> ADP + dGMP

NTP + 2'-Deoxycytidine <-> dCMP + NDP

ATP + 2'-Deoxycytidine <-> ADP + dCMP

ATP + Cytarabine <-> ADP + 1-beta-D-Arabinofuranosylcytosine 5'-monophosphate

ATP + Zalcitabine <-> ADP + L-ddCMP

ATP + L-2'-Deoxycarbocyclic guanosine <-> ADP + L-2'-Deoxycarbocyclic guanosine 5'-phosphate

ATP + D-2'-Deoxycarbocyclic guanosine <-> ADP + D-2'-Deoxycarbocyclic guanosine 5'-phosphate

ATP + Vidarabine <-> ADP + 9-beta-D-Arabinofuranosyladenine 5'-monophosphate

GTP + 2'-Deoxycytidine <-> dCMP + GDP

CTP + 2'-Deoxycytidine <-> dCMP + CDP

ATP + Cytidine <-> ADP + CMP

ATP + Gemcitabine <-> ADP + Gemcitabine monophosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.7.1.74