Enzyme Details

EC Classification

3.1.1.1

Enzyme name
(recommended)

carboxylesterase

Alternative names

methylbutyrase
carboxylic-ester hydrolase
ali-esterase
B-esterase
monobutyrase
cocaine esterase
procaine esterase
methylbutyrase
vitamin A esterase
butyryl esterase
carboxyesterase
carboxylate esterase
carboxylic esterase
methylbutyrate esterase
triacetin esterase
carboxyl ester hydrolase
butyrate esterase
alpha-carboxylesterase
propionyl esterase
nonspecific carboxylesterase
esterase D
esterase B
esterase A
serine esterase
carboxylic acid esterase
cocaine esterase

Classification

Hydrolases

Acting on ester bonds

Carboxylic ester hydrolases

Catalyses reactions

H2O + Carboxylic ester <-> Alcohol + Carboxylate

H2O + All-trans-Retinyl palmitate <-> Palmitate + Retinol

H2O + Cocaine <-> Benzoate + Ecgonine methyl ester

H2O + p-Nitrophenyl caproate <-> Hexanoate + p-Nitrophenol

H2O + p-Nitrophenyl dodecanoate <-> Dodecanoate + p-Nitrophenol

H2O + Valacyclovir <-> L-Valine + Acyclovir

H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol

H2O + Phenylacetic acid <-> Acetate + Phenol

H2O + p-Nitrophenyl propionate <-> Propanoate + p-Nitrophenol

H2O + 1-Naphthylacetic acid <-> Acetate + alpha-Naphthol

H2O + p-Nitrophenyl butyrate <-> Butanoate + p-Nitrophenol

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + alpha-Cyano-(6-methoxy-2-naphthyl)-methyl-2,2,3,3-tetramethylcyclopropane-1-carboxylate <-> alpha-Cyano-(6-methoxy-2-naphthyl)-methanol + 1-Carboxy-2,2,3,3-tetramethylcyclopropane

H2O + alpha-Cyano-(6-methoxy-2-naphthyl)-methyl-3-(2,2-dimethylvinyl)-2,2-dimethylcyclopropane carboxylate <-> alpha-Cyano-(6-methoxy-2-naphthyl)-methanol + 3-(2,2-Dimethylvinyl)-2,2-dimethylcyclopropane carboxylate

H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2R)-2-(4-chlorophenyl)-3-methyl butanoate <-> (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (2R)-2-(4-Chlorophenyl)-3-methyl butanoate

H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + Cypermethrin <-> 3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + alpha-Cyano(3-phenoxyphenyl)methanol

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2R)-2-(4-chlorophenyl)-3-methyl butanoate <-> (2R)-2-(4-Chlorophenyl)-3-methyl butanoate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2S)-2-(4-chlorophenyl)-3-methyl butanoate <-> (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (2S)-2-(4-Chlorophenyl)-3-methyl butanoate

H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol

H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (1R)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate

H2O + cis-Permethrin <-> 3-Phenoxybenzyl alcohol + cis-Dichlorochrysanthemic acid

H2O + 1-RS-trans-Permethrin <-> 3-Phenoxybenzyl alcohol + 1-R,S-trans-Dichlorochrysanthemic acid

H2O + Resmethrin <-> Methylchrysanthemic acid + 5-Benzyl-3-furylmethyl alcohol

H2O + trans-Permethrin <-> 3-Phenoxybenzyl alcohol + trans-Dichlorochrysanthemic acid

H2O + 1-R,S-cis-Permethrin <-> 1-R,S-cis-Dichlorochrysanthemic acid + 3-Phenoxybenzyl alcohol

H2O + alpha-Cypermethrin <-> alpha-R,S-Cyano-(3-phenoxyphenyl)methyl alcohol + cis-Dichlorochrysanthemic acid

H2O + p-Nitrophenyl valerate <-> Pentanoate + p-Nitrophenol

H2O + Cholesteryl oleate <-> Cholesterol + Oleate

H2O + Trioleoylglycerol <-> Oleate + sn-1,2-Dioleoylglycerol

H2O + Ethyl hexanoate <-> Ethanol + Hexanoate

H2O + Ethyl pentanoate <-> Ethanol + Pentanoate

H2O + p-Nitrophenyl octanoate <-> Octanoate + p-Nitrophenol

H2O + p-Nitrophenyl decanoate <-> Decanoate + p-Nitrophenol

H2O + Ethyl propionate <-> Ethanol + Propanoate

H2O + Ethyl butanoate <-> Ethanol + Butanoate

H2O + Phenylthioacetate <-> Phenol + Thioacetate

H2O + Hexanoyl acetate <-> Acetate + Hexanol

H2O + Butyl acetate <-> Acetate + Butanol

H2O + Propyl acetate <-> Acetate + 1-Propanol

H2O + Acetic ester <-> Ethanol + Acetate

H2O + 1-Naphthylbutanoic acid <-> Butanoate + alpha-Naphthol

H2O + p-Nitrophenyl hexadecanoate <-> Palmitate + p-Nitrophenol

H2O + p-Nitrophenyl tetradecanoate <-> Myristic acid + p-Nitrophenol

H2O + Deltamethrin <-> Cyanide + 3-Phenoxybenzaldehyde + cis-Dibromochrysanthemic acid

H2O + Esfenvalerate <-> Cyanide + cis-Dichlorochrysanthemic acid + 3-Phenoxybenzaldehyde

H2O + Benzocaine <-> Ethanol + 4-Aminobenzoate

H2O + Propyl 4-aminobenzoate <-> 4-Aminobenzoate + 1-Propanol

H2O + Butyl 4-aminobenzoate <-> 4-Aminobenzoate + Butanol

H2O + p-Nitrophenyl laurate <-> Dodecanoate + p-Nitrophenol

H2O + Oseltamivir <-> Unknown + Oseltamivir carboxylate

H2O + L-Methylphenidate <-> Methanol + Ritalinic acid

H2O + D-Methylphenidate <-> Methanol + Ritalinic acid

H2O + o-Nitrophenyl acetate <-> Acetate + o-Nitrophenol

H2O + 5'-L-Phenylalanyl-floxuridine <-> L-Phenylalanine + 5-Fluorodeoxyuridine

H2O + 5'-D-Phenylalanyl-floxuridine <-> D-Phenylalanine + 5-Fluorodeoxyuridine

H2O + 3'-D-Phenylalanyl-floxuridine <-> D-Phenylalanine + 5-Fluorodeoxyuridine

H2O + 3'-L-Phenylalanyl-floxuridine <-> L-Phenylalanine + 5-Fluorodeoxyuridine

H2O + 5'-L-Prolyl-floxuridine <-> L-Proline + 5-Fluorodeoxyuridine

H2O + 3'-L-Prolyl-floxuridine <-> L-Proline + 5-Fluorodeoxyuridine

H2O + 5'-L-Leucyl-floxuridine <-> L-Leucine + 5-Fluorodeoxyuridine

H2O + 3'-L-Leucyl-floxuridine <-> L-Leucine + 5-Fluorodeoxyuridine

H2O + 3'-L-Lysyl-floxuridine <-> L-Lysine + 5-Fluorodeoxyuridine

H2O + 5'-L-Lysyl-floxuridine <-> L-Lysine + 5-Fluorodeoxyuridine

H2O + 3'-L-Isoleucyl-floxuridine <-> L-Isoleucine + 5-Fluorodeoxyuridine

H2O + 3'-L-Aspartyl-floxuridine <-> L-Aspartate + 5-Fluorodeoxyuridine

H2O + 5'-L-Aspartyl-floxuridine <-> L-Aspartate + 5-Fluorodeoxyuridine

H2O + 5'-D-Valyl-floxuridine <-> D-Valine + 5-Fluorodeoxyuridine

H2O + 5'-L-Valyl-floxuridine <-> L-Valine + 5-Fluorodeoxyuridine

H2O + 3'-L-Valyl-floxuridine <-> L-Valine + 5-Fluorodeoxyuridine

H2O + 3'-D-Valyl-floxuridine <-> D-Valine + 5-Fluorodeoxyuridine

H2O + 5'-L-Isoleucyl-floxuridine <-> L-Isoleucine + 5-Fluorodeoxyuridine

H2O + 3'-L-Phenylalanyl-gemcitabine <-> L-Phenylalanine + Gemcitabine

H2O + 3'-D-Phenylalanyl-gemcitabine <-> D-Phenylalanine + Gemcitabine

H2O + 5'-L-Phenylalanyl-gemcitabine <-> L-Phenylalanine + Gemcitabine

H2O + 5'-D-Phenylalanyl-gemcitabine <-> D-Phenylalanine + Gemcitabine

H2O + 3'-L-Valyl-gemcitabine <-> L-Valine + Gemcitabine

H2O + 3'-L-Isoleucyl-gemcitabine <-> L-Isoleucine + Gemcitabine

H2O + 3'-D-Valyl-gemcitabine <-> D-Valine + Gemcitabine

H2O + 5'-L-Isoleucyl-gemcitabine <-> L-Isoleucine + Gemcitabine

H2O + 5'-D-Valyl-gemcitabine <-> D-Valine + Gemcitabine

H2O + 5'-L-Valyl-gemcitabine <-> L-Valine + Gemcitabine

H2O + 5'-L-Phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole <-> L-Phenylalanine + 2-Bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole

H2O + 5'-D-Phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole <-> D-Phenylalanine + 2-Bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole

H2O + L-Phenylalanine ethyl ester <-> Ethanol + L-Phenylalanine

H2O + L-Phenylalanine benzyl ester <-> L-Phenylalanine + Benzol

H2O + N-Acetyl-L-phenylalanine ethyl ester <-> Ethanol + N-Acetyl-L-phenylalanine

H2O + Irinotecan <-> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid

H2O + 5'-Cinnamic acid-floxuridin <-> Cinnamic acid + 5-Fluorodeoxyuridine

H2O + 3-Methylbutanol-cysteinylglycine <-> Glycine + Felinine

H2O + Nafamostat <-> p-Guanidinobenzoic acid + 6-Amidino-2-naphthol

H2O + Capecitabine <-> Unknown + 5'-Deoxy-5-fluorocytidine

H2O + 4-Methylumbelliferyl acetate <-> Acetate + 4-Methylumbelliferone

H2O + 4-Methylumbelliferyl butyrate <-> Butanoate + 4-Methylumbelliferone

H2O + 4-Methylumbelliferyl heptanoate <-> 4-Methylumbelliferone + Heptanoate

H2O + 4-Methylumbelliferyl octanoate <-> Octanoate + 4-Methylumbelliferone

H2O + 4-Methylumbelliferyl laurate <-> Dodecanoate + 4-Methylumbelliferone

H2O + 4-Methylumbelliferyl palmitate <-> Palmitate + 4-Methylumbelliferone

H2O + 7-Ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin <-> SN-38 + 4-Amino-1-piperidinecarboxylic acid

H2O + 7-Ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin <-> SN-38 + 4-((4-Carboxybutyl)amino)piperidine-1-carboxylic acid

H2O + Triacetin <-> Acetate + Diacetin

H2O + Tripropionin <-> Propanoate + Glycerol dipropionate

H2O + Tributyrin <-> Butanoate + Dibutyrylglycerol

H2O + Tricaprilin <-> Octanoate + Dioctanoylglycerol

H2O + Trioleoylglycerol <-> Oleate + Dioleoylglycerol

H2O + Vinylacetate <-> Acetate + Polyvinyl alcohol

H2O + Vinyl propionate <-> Propanoate + Polyvinyl alcohol

H2O + Vinyl butyrate <-> Butanoate + Polyvinyl alcohol

H2O + Vinyl laurate <-> Dodecanoate + Polyvinyl alcohol

H2O + Palmityl oleate <-> Oleate + 1-Hexadecanol

H2O + Methyl indole-3-acetate <-> Methanol + Indole-3-acetate

External links

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BRENDA
IntEnz (EBI)
IUBMB
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