Enzyme Details

EC Classification

3.1.2.6

Enzyme name
(recommended)

hydroxyacylglutathione hydrolase

Alternative names

S-(2-hydroxyacyl)glutathione hydrolase
glyoxalase II
S-2-hydroxylacylglutathione hydrolase
hydroxyacylglutathione hydrolase
acetoacetylglutathione hydrolase

Classification

Hydrolases

Acting on ester bonds

Thiolester hydrolases

Catalyses reactions

H2O + S-(2-Hydroxyacyl)glutathione <-> Reduced glutathione + 2-Hydroxycarboxylate

H2O + (R)-S-Lactoylglutathione <-> Reduced glutathione + D-Lactate

H2O + S-Succinylglutathione <-> Succinate + Reduced glutathione

H2O + S-Formylglutathione <-> Formate + Reduced glutathione

H2O + S-Lactoylglutathione <-> Reduced glutathione + Lactate

H2O + (R)-S-Mandeloylglutathione <-> Reduced glutathione + (R)-Mandelate

H2O + (S)-S-Glyceroylglutathione <-> Reduced glutathione + L-Glycerate

H2O + S-Acetoacetylglutathione <-> Reduced glutathione + Acetoacetate

H2O + S-Glycolylglutathione <-> Reduced glutathione + Glycolylate

H2O + S-Acetylglutathione <-> Acetate + Reduced glutathione

H2O + Lactoylglutathione <-> Reduced glutathione + D-Lactate

H2O + Bis-(lactoyl)trypanothione <-> 2 D-Lactate + Reduced trypanothione

H2O + (R)-S-Lactoyltrypanothione <-> D-Lactate + Reduced trypanothione

H2O + Mono-(lactoyl)trypanothione <-> D-Lactate + Reduced trypanothione

H2O + S-(beta-Ethoxy-alpha-D-hydroxybutyryl)glutathione <-> Reduced glutathione + beta-Ethoxy-alpha-D-hydroxybutyrate

H2O + S-Propionylglutathione <-> Reduced glutathione + Propanoate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.1.2.6