Enzyme Details

EC Classification

3.1.3.48

Enzyme name
(recommended)

protein-tyrosine-phosphatase

Alternative names

protein-tyrosine-phosphate phosphohydrolase
phosphotyrosine phosphatase
phosphoprotein phosphatase (phosphotyrosine)
phosphotyrosine histone phosphatase
protein phosphotyrosine phosphatase
tyrosylprotein phosphatase
phosphotyrosine protein phosphatase
phosphotyrosylprotein phosphatase
tyrosine O-phosphate phosphatase
PPT-phosphatase
PTPase
[phosphotyrosine]protein phosphatase
PTP-phosphatase

Classification

Hydrolases

Acting on ester bonds

Phosphoric monoester hydrolases

Catalyses reactions

H2O + Protein tyrosine phosphate <-> Phosphate + Protein tyrosine

H2O + 4-Nitrophenyl phosphate <-> Phosphate + p-Nitrophenol

H2O + beta-Naphthyl phosphate <-> Phosphate + beta-Naphthol

H2O + Phenolic phosphate <-> Phosphate + Phenol

H2O + 8-Fluoro-4-methylumbelliferyl phosphate <-> Phosphate + 8-Fluoro-4-methylumbelliferone

H2O + 6-Fluoro-4-methylumbelliferyl phosphate <-> Phosphate + 6-Fluoro-4-methylumbelliferone

H2O + 6,8-Difluoro-4-methylumbelliferyl phosphate <-> Phosphate + 6,8-Difluoro-4-methylumbelliferone

H2O + 5-Fluoro-4-methylumbelliferyl phosphate <-> Phosphate + 5-Fluoro-4-methylumbelliferone

H2O + 4-Trifluoromethylphenyl phosphate <-> Phosphate + 4-Trifluoromethylphenol

H2O + 4-Methylumbelliferyl phosphate <-> Phosphate + 4-Methylumbelliferone

H2O + 4-Cyanophenyl phosphate <-> Phosphate + 4-Cyanophenol

H2O + 4-Chlorophenyl phosphate <-> Phosphate + 4-Chlorophenol

H2O + 3-O-Methylfluorescein phosphate <-> Phosphate + 3-O-Methylfluorescein

H2O + 2-Chloro-4-nitrophenyl phosphate <-> Phosphate + 2-Chloro-4-nitrophenol

H2O + 3-Chlorophenyl phosphate <-> Phosphate + 3-Chlorophenol

H2O + 3-Nitrophenyl phosphate <-> Phosphate + 3-Nitrophenol

H2O + 4-Ethylphenyl phosphate <-> Phosphate + 4-Ethylphenol

H2O + 4-Fluorophenyl phosphate <-> Phosphate + p-Fluorophenol

H2O + Phosphotyrosine <-> Phosphate + Tyrosine

H2O + Proteine tyrosine phosphate <-> Phosphate + Protein tyrosine

((IFNRJ2_activated)(SHP2)) <-> IFNRJ2 + SHP2

H2O + L-Phosphotyrosine <-> Phosphate + L-Tyrosine

H2O + Adenosine 2'-phosphate <-> Phosphate + Adenosine

H2O + Protein tyrosine diphosphate <-> 2 Phosphate + Protein tyrosine

H2O + P-Erk2 <-> Phosphate + Erk2

Abietate + PTP1B <-> Enzyme-inhibitor complex

Dehydroabietic acid + PTP1B <-> Enzyme-inhibitor complex

H2O + Fluorescein diphosphate <-> Phosphate + Fluorescein monophosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.1.3.48

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