Enzyme Details

EC Classification

3.4.21

Enzyme name
(recommended)

Serine endopeptidases

Classification

Hydrolases

Acting on peptide bonds (peptide hydrolases)

Serine endopeptidases

Catalyses reactions

H2O + 2-Aminobenzoyl-KLRSGKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SGKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRSPKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SPKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KQRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KQR

H2O + 2-Aminobenzoyl-VLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-VLR

H2O + 2-Aminobenzoyl-HLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-HLR

H2O + 2-Aminobenzoyl-KPRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KPR

H2O + 2-Aminobenzoyl-KTRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KTR

H2O + 2-Aminobenzoyl-KVRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KVR

H2O + 2-Aminobenzoyl-KLRRSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + RSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRSVKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SVKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KHRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KHR

H2O + 2-Aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + VSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-ILRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-ILR

H2O + 2-Aminobenzoyl-KLRLSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + LSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRNSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> NSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-QLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-QLR

H2O + 2-Aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SIKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRSHKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SHKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KRRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KRR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRSRKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SRKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-NLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-NLR

H2O + 2-Aminobenzoyl-KLRGSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + GSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KGRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KGR

H2O + 2-Aminobenzoyl-KFRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KFR

H2O + 2-Aminobenzoyl-FLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-FLR

H2O + 2-Aminobenzoyl-KLRSQKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + SQKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KWRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KWR + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRHSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> HSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRQSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> QSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KYRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KYR

H2O + 2-Aminobenzoyl-KERSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KER

H2O + 2-Aminobenzoyl-RLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-RLR

H2O + 2-Aminobenzoyl-KLRSEKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SEKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-LLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-LLR

H2O + 2-Aminobenzoyl-KLRESKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> ESKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRASKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> ASKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KARSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KAR

H2O + 2-Aminobenzoyl-ELRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-ELR

H2O + 2-Aminobenzoyl-KLRISKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> ISKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRSFKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SFKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KNRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KNR

H2O + 2-Aminobenzoyl-KIRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KIR

H2O + 2-Aminobenzoyl-KMRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KMR

H2O + 2-Aminobenzoyl-KLRSAKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SAKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRSLKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SLKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KLRFSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> 2-Aminobenzoyl-KLR + FSKQ-N-(2,4-dinitrophenyl)ethylenediamine

H2O + 2-Aminobenzoyl-KLRSNKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SNKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KLR

H2O + 2-Aminobenzoyl-KSRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-KSR

H2O + 2-Aminobenzoyl-GLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-GLR

H2O + 2-Aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine <-> SSKQ-N-(2,4-dinitrophenyl)ethylenediamine + 2-Aminobenzoyl-ALR

H2O + t-Butyloxycarbonyl-Ile-Glu-Gly-Arg-4-methylcoumarin-7-ylamide <-> t-Butyloxycarbonyl-Ile-Glu-Gly-Arg + 7-Amino-4-methylcoumarin

H2O + t-Butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumarin-7-ylamide <-> t-Butyloxycarbonyl-Gln-Ala-Arg + 7-Amino-4-methylcoumarin

H2O + t-Butyloxycarbonyl-Phe-Ser-Arg-4-methylcoumarin-7-ylamide <-> t-Butyloxycarbonyl-Phe-Ser-Arg + 7-Amino-4-methylcoumarin

H2O + Asn-Ala-Arg-ACC <-> ACC + Asn-Ala-Arg

H2O + Succinyl-RRYIKASEPPV-NH2 <-> SEPPV-NH2 + Succinyl-RRYIKA

H2O + Succinyl-KSTYIKASEPPVRR-NH2 <-> SEPPVRR-NH2 + Succinyl-KSTYIKA

H2O + Succinyl-STYIKASEPPVRR-NH2 <-> SEPPVRR-NH2 + Succinyl-STYIKA

H2O + Succinyl-TYIKASEPPVRR-NH2 <-> SEPPVRR-NH2 + Succinyl-TYIKA

H2O + Succinyl-YIKASEPPVRR-NH2 <-> Succinyl-YIKA + SEPPVRR-NH2

H2O + Succinyl-IKASEPPVRR-NH2 <-> Succinyl-IKA + SEPPVRR-NH2

H2O + Succinyl-RRYIKASEPP-NH2 <-> Succinyl-RRYIKA + SEPP-NH2

H2O + Succinyl-RRYIKASEP-NH2 <-> Succinyl-RRYIKA + SEP-NH2

H2O + Succinyl-Arg-Arg-Tyr-Ile-Lys-Ala-Ser-Glu-Pro-Pro-NH2 <-> Ser-Glu-Pro-Pro-NH2 + Succinyl-Arg-Arg-Tyr-Ile-Lys-Ala-

H2O + Succinyl-Arg-Arg-Ile-Ile-Lys-Ala-Ser-Glu-Pro-Pro-NH2 <-> Ser-Glu-Pro-Pro-NH2 + Succinyl-Arg-Arg-Ile-Ile-Lys-Ala-

H2O + Succinyl-Arg-Arg-Nle-Ile-Lys-Ala-Ser-Glu-Pro-Pro-NH2 <-> Ser-Glu-Pro-Pro-NH2 + Succinyl-Arg-Arg-Nle-Ile-Lys-Ala-

H2O + Succinyl-Arg-Arg-Asp-Ile-Lys-Ala-Ser-Glu-Pro-Pro-NH2 <-> Ser-Glu-Pro-Pro-NH2 + Succinyl-Arg-Arg-Asp-Ile-Lys-Ala-

H2O + L-Pyroglutamic acid-cyclohexylglycine-Arg-p-nitroanilide <-> 4-Nitroaniline + L-Pyroglutamic acid-cyclohexylglycine-Arg

H2O + N-Benzoyl-L-arginine ethyl ester <-> Ethanol + N-Benzoyl-L-arginine

H2O + N-Carboxybenzyloxyglycine-L-arginine thiobenzyl ester <-> Benzylthiol + N-Carboxybenzyloxyglycine-L-arginine

H2O + Ac-Tyr-OEt <-> Ethanol + N-Acetyl-L-tyrosine

H2O + N-Benzoyl-L-tyrosine ethyl ester <-> Ethanol + N-Benzoyl-L-tyrosine

H2O + N-Acetyl-L-phenylalanine ethyl ester <-> Ethanol + N-Acetyl-L-phenylalanine

H2O + Hemoglobin <-> hydrolyzed Hemoglobin

H2O + Benzyloxycarbonyl-phenylalanine-arginine 4-methylcoumarin-7-ylamide <-> Benzyloxycarbonyl-Phe-Arg + 7-Amino-4-methylcoumarin

H2O + alpha-N-Acetyl-Leu-Leu-Arg-4-nitroanilide <-> 4-Nitroaniline + alpha-N-Acetyl-Leu-Leu-Arg

H2O + alpha-N-Acetyl-Leu-Lys-Arg-4-nitroanilide <-> 4-Nitroaniline + alpha-N-Acetyl-Leu-Lys-Arg

H2O + alpha-N-Benzyloxycarbonyl-Ala-Ala-Ala-Arg-4-nitroanilide <-> 4-Nitroaniline + alpha-N-Benzyloxycarbonyl-Ala-Ala-Ala-Arg

H2O + alpha-N-Benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg-4-nitroanilide <-> 4-Nitroaniline + alpha-N-Benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg

H2O + alpha-N-Succinyl-Ala-Ala-Phe-4-nitroanilide <-> 4-Nitroaniline + alpha-N-Succinyl-Ala-Ala-Phe

H2O + Phe-Met-Arg-Phe-NH2 <-> NH3 + Phe-Met-Arg-Phe

H2O + LEEELKPLEEVLNL <-> LEEVLNL + LEEELKPL

Complement component C3 <-> Complement component C3b + Complement component C3a

Complement component C3i <-> Complement component C3b + Complement component C3a

H2O + Complement component C2 <-> Complement component C2a + Complement component C2b

H2O + Complement component C4 <-> Complement component C4b + Complement component C4a

H2O + p-Tosyl-L-arginine methyl ester <-> Methanol + p-Tosyl-L-arginine

H2O + N-Benzoyl-L-arginine-4-nitroanilide <-> 4-Nitroaniline + N-Benzoyl-L-arginine

H2O + D-Phe-Pip-Arg-p-nitroanilide <-> 4-Nitroaniline + D-Phe-Pip-Arg

H2O + D-Val-Leu-Lys-p-nitroanilide <-> 4-Nitroaniline + D-Val-Leu-Lys

H2O + Phe-Ser-Arg-7-Amino-4-methylcoumarin <-> Phe-Ser-Arg + 7-Amino-4-methylcoumarin

H2O + Gly-Gly-Arg-7-Amino-4-methylcoumarin <-> Gly-Gly-Arg + 7-Amino-4-methylcoumarin

H2O + Asp-Pro-Arg-7-Amino-4-methylcoumarin <-> Asp-Pro-Arg + 7-Amino-4-methylcoumarin

H2O + Gln-Gly-Arg-7-Amino-4-methylcoumarin <-> Gln-Gly-Arg + 7-Amino-4-methylcoumarin

H2O + Pro-Phe-Arg-7-Amino-4-methylcoumarin <-> Pro-Phe-Arg + 7-Amino-4-methylcoumarin

H2O + Val-Pro-Arg-7-Amino-4-methylcoumarin <-> Val-Pro-Arg + 7-Amino-4-methylcoumarin

H2O + Val-Leu-Lys-7-Amino-4-methylcoumarin <-> Val-Leu-Lys + 7-Amino-4-methylcoumarin

H2O + ABZ-Dap(O2(Cbz))-Dap(Cbz)-Dap(GO1)-Arg-ANB-NH2 <-> ANB-NH2 + ABZ-Dap(O2(Cbz))-Dap(Cbz)-Dap(GO1)-Arg-OH

H2O + Plasminogen <-> Plasmin

H2O + N-alpha-Benzoyl-DL-Arg-p-nitroanilide <-> 4-Nitroaniline + N-alpha-Benzoyl-DL-arginine

H2O + D-Pro-Phe-Arg-p-nitroanilide <-> 4-Nitroaniline + D-Pro-Phe-Arg

H2O + D-Val-Leu-Arg-p-nitroanilide <-> 4-Nitroaniline + D-Val-Leu-Arg

H2O + Bz-Ile-Glu-Gly-Arg-p-nitroanilide <-> 4-Nitroaniline + Bz-Ile-Glu-Gly-Arg

H2O + Tosyl-Gly-Pro-Lys-p-nitroanilide <-> 4-Nitroaniline + Tosyl-Gly-Pro-Lys

H2O + Benzoyl-Pro-Phe-Arg-p-nitroanilide <-> 4-Nitroaniline + Benzoyl-Pro-Phe-Arg

H2O + Benzoyl-Phe-Val-Arg-p-nitroanilide <-> 4-Nitroaniline + Benzoyl-Phe-Val-Arg

H2O + Benzoyl-Val-Gly-Arg-p-nitroanilide <-> 4-Nitroaniline + Benzoyl-Val-Gly-Arg

H2O + Protein C <-> Dodecapeptide + activated Protein C

H2O + Tosyl-Gly-Pro-Arg-p-nitroanilide <-> 4-Nitroaniline + Tosyl-Gly-Pro-Arg

H2O + Ile-Pro-Arg-p-nitroanilide <-> 4-Nitroaniline + Ile-Pro-Arg

H2O + Abz-YQTFFNPRTFGSQ-EDDnp <-> TFGSQ-EDDnp + Abz-YQTFFNPR

H2O + L-Pyroglutamyl-Phe-Lys-p-nitroanilide <-> 4-Nitroaniline + L-Pyroglutamyl-Phe-Lys

H2O + L-Pyroglutamyl-Pro-Arg-p-nitroanilide <-> 4-Nitroaniline + L-Pyroglutamyl-Pro-Arg

H2O + L-Pyroglutamyl-Gly-Arg-p-nitroanilide <-> 4-Nitroaniline + L-Pyroglutamyl-Gly-Arg

H2O + n GroEL2 <-> n GroEL2 cleaved

External links

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