Enzyme Details

EC Classification

3.5.2.6

Enzyme name
(recommended)

beta-lactamase

Alternative names

neutrapen
beta-lactam hydrolase
penicillinase
cephalosporinase
penicillin beta-lactamase
exopenicillinase
ampicillinase
penicillin amido-beta-lactamhydrolase
penicillinase I, II
beta-lactamase I-III
beta-lactamase A, B, C
beta-lactamase AME I
cephalosporin-beta-lactamase

Classification

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amides

Catalyses reactions

H2O + Cephalosporin C <-> Acetate + Deacetylcephalosporin C

H2O + beta-Lactam <-> Substituted beta-amino acid

H2O + Penicillin G <-> 2-Phenyl acetate + 6-Aminopenicillanate

H2O + Penicillin G <-> Substituted beta-amino acid

H2O + Penicillin <-> Penicilloic acid

H2O + Biapenem <-> Substituted beta-amino acid

H2O + Cephalothin <-> Substituted beta-amino acid

H2O + Imipenem <-> Substituted beta-amino acid

H2O + Meropenem <-> Substituted beta-amino acid

H2O + Nitrocefin <-> Substituted beta-amino acid

H2O + Oxacillin <-> Substituted beta-amino acid

H2O + Cloxacillin <-> Substituted beta-amino acid

H2O + Carbenicillin <-> Substituted beta-amino acid

H2O + Bocillin FL <-> Substituted beta-amino acid

H2O + Ampicillin <-> Substituted beta-amino acid

H2O + 6-beta-Hydroxymethylpenicillanate <-> Substituted beta-amino acid

H2O + 6-beta-(1-Hydroxyethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-beta-(1-Hydroxy-1-methylethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-Hydroxymethylpenicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-(1-Hydroxyethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-(1-Hydroxy-1-methylethyl)-penicillanate <-> Substituted beta-amino acid

H2O + Cephalosporin <-> Substituted beta-amino acid

H2O + Cefuroxime <-> Substituted beta-amino acid

H2O + Cefotaxime <-> Substituted beta-amino acid

H2O + 3-[2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid <-> 3-Hydroxybenzoate + 2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetylglycine

H2O + 3-[(Phenylacetyl)glycyl]oxybenzoic acid <-> 3-Hydroxybenzoate + Phenylacetylglycine

H2O + Dexamethasone-Cephem-Methotrexate <-> Dexamethasone-Cephem derivative + Methotrexate-thiol

H2O + Cefcapene <-> Substituted beta-amino acid

H2O + Cefdinir <-> Substituted beta-amino acid

H2O + Ceftazidime <-> Substituted beta-amino acid

H2O + Cephaloridine <-> Substituted beta-amino acid

H2O + Piperacillin <-> Substituted beta-amino acid

H2O + Sulbactam <-> Substituted beta-amino acid

H2O + Cefaclor <-> Substituted beta-amino acid

H2O + Cefoxitin <-> Substituted beta-amino acid

H2O + Cephapirin <-> Substituted beta-amino acid

H2O + Cefamandole <-> Substituted beta-amino acid

H2O + Cefazolin <-> Substituted beta-amino acid

H2O + Cephalexin <-> Substituted beta-amino acid

H2O + Moxalactam <-> Substituted beta-amino acid

H2O + 6-beta-Iodopenicillanic acid <-> Substituted beta-amino acid

H2O + Cephaloglycin <-> Substituted beta-amino acid

H2O + Cephaloridin <-> Substituted beta-amino acid

H2O + Cephazoline <-> Substituted beta-amino acid

H2O + Cefoperazone <-> Substituted beta-amino acid

H2O + Methicillin <-> Substituted beta-amino acid

H2O + Mecillinam <-> Substituted beta-amino acid

H2O + Amoxycillin <-> Substituted beta-amino acid

H2O + Aztreonam <-> Substituted beta-amino acid

H2O + Ticarcillin <-> Substituted beta-amino acid

H2O + 6-Aminopenicillanate <-> Substituted beta-amino acid

H2O + Ticaracillin <-> Substituted beta-amino acid

H2O + Cefpirome <-> Substituted beta-amino acid

H2O + Loracarbef <-> Substituted beta-amino acid

H2O + Amoxicillin <-> Substituted beta-amino acid

H2O + Mezlocillin sodium <-> Substituted beta-amino acid

H2O + Ceftriaxone <-> Substituted beta-amino acid

H2O + Cephalosporin C <-> Substituted beta-amino acid

H2O + Cefotiam <-> Substituted beta-amino acid

H2O + Cefepime <-> Substituted beta-amino acid

H2O + 7-Aminocephalosporanic acid <-> Substituted beta-amino acid

H2O + Cefotetan <-> Substituted beta-amino acid

H2O + Azlocillin <-> Substituted beta-amino acid

H2O + Talampicillin <-> Substituted beta-amino acid

H2O + Cephradine <-> Substituted beta-amino acid

H2O + CGP-31608A <-> Substituted beta-amino acid

H2O + HRE-664 <-> Substituted beta-amino acid

H2O + Sulbenicillin <-> Substituted beta-amino acid

H2O + CGP-31523A <-> Substituted beta-amino acid

H2O + Epicillin <-> Substituted beta-amino acid

H2O + Temocillin <-> Substituted beta-amino acid

H2O + CGP-17520A <-> Substituted beta-amino acid

H2O + Tazobactam <-> Substituted beta-amino acid

H2O + CP-65207 <-> Substituted beta-amino acid

H2O + Asparenomycin A <-> Substituted beta-amino acid

H2O + Cefsulodin <-> Substituted beta-amino acid

H2O + 6-beta-Furylacryloylamidopenicillanic acid <-> Substituted beta-amino acid

H2O + Penicillin V <-> Substituted beta-amino acid

H2O + Cefprozil <-> Substituted beta-amino acid

H2O + BRL42715 <-> Substituted beta-amino acid

H2O + Cefadroxil <-> Substituted beta-amino acid

H2O + Cefmetazole <-> Substituted beta-amino acid

H2O + Clavulanic acid <-> Substituted beta-amino acid

H2O + Pyridine-2-azo-4-dimethylaniline cephalosporin <-> Substituted beta-amino acid

H2O + Ceftizoxime <-> Substituted beta-amino acid

H2O + N-(2-Furyl)acryloylpenicillin <-> Substituted beta-amino acid

H2O + SY55555 <-> Substituted beta-amino acid

H2O + Cefteram <-> Substituted beta-amino acid

H2O + Cefixime <-> Substituted beta-amino acid

H2O + (3-Hydroxymethyl)-phenoxymethylpenicillin <-> Substituted beta-amino acid

H2O + Benzylpenicillin methyl ester <-> Substituted beta-amino acid

H2O + Deacetylcephalosporin C <-> Substituted beta-amino acid

H2O + Deacetylcephalosporin C lactone <-> Substituted beta-amino acid

H2O + Carbenicillin methyl ester <-> Substituted beta-amino acid

H2O + L-695,256 <-> Substituted beta-amino acid

H2O + Cefpodoxime <-> Substituted beta-amino acid

H2O + Furopenem <-> Substituted beta-amino acid

H2O + DU-66881a <-> Substituted beta-amino acid

H2O + Doripenem <-> Substituted beta-amino acid

H2O + Faropenem sodium <-> Substituted beta-amino acid

H2O + LJC 10,627 <-> Substituted beta-amino acid

H2O + CENTA <-> Substituted beta-amino acid

H2O + Ertapenem <-> Substituted beta-amino acid

H2O + Carumonam <-> Substituted beta-amino acid

H2O + Desacetyl cefotaxime <-> Substituted beta-amino acid

H2O + 2-Ethylthio-(6S,8R)hydroxyethylpeneme <-> Unknown

H2O + Panipenem <-> Substituted beta-amino acid

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.5.2.6

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