Enzyme Details

EC Classification

4.2.1.36

Enzyme name
(recommended)

homoaconitate hydratase

Alternative names

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]
homoaconitase
cis-homoaconitase
HACN
Lys4
LysF
2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase (incorrect)

Classification

Lyases

Carbon-oxygen lyases

Hydro-lyases

Catalyses reactions

D-Malate <-> H2O + Maleate

Homocitrate <-> H2O + But-1-ene-1,2,4-tricarboxylate

Homoisocitrate <-> H2O + But-1-ene-1,2,4-tricarboxylate

H2O + cis-Homo(2)-aconitate <-> Homo(2)-citrate

H2O + cis-Homo(3)-aconitate <-> Homo(3)-citrate

H2O + cis-Homo(4)-aconitate <-> Homo(4)-citrate

H2O + cis-Homo(2)-aconitate <-> Homo(2)-isocitrate

H2O + cis-Homo(3)-aconitate <-> Homo(3)-isocitrate

H2O + cis-Homo(4)-aconitate <-> Homo(4)-isocitrate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 4.2.1.36