Enzyme Details

EC Classification

4.2.3.12

Enzyme name
(recommended)

6-pyruvoyltetrahydropterin synthase

Alternative names

7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)
2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)

Classification

Lyases

Carbon-oxygen lyases

Acting on phosphates

Catalyses reactions

H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin

3 H2O + 2-Amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-dihydroxypteridine triphosphate <-> 3 Phosphate + 2-Amino-4-oxo-6-(1',2'-dioxoprolyl)-7,8-dihydroxypteridine

7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 4.2.3.12