Enzyme Details

 EC Classification 5.3.99.4
 Enzyme name
(recommended)
prostaglandin-I synthase
 Alternative names (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
prostacyclin synthase
prostacycline synthetase
prostagladin I2 synthetase
PGI2 synthase
PGI2 synthetase
 Classification
Isomerases
Intramolecular oxidoreductases
Other intramolecular oxidoreductases
 Catalyses reactions
Prostaglandin H2 <-> Prostaglandin I2
Prostaglandin H1 <-> Malondialdehyde + 12-Hydroxy-8,10-heptadecadienoic acid
Prostaglandin H2 <-> Prostaglandin D2
Carbon monoxide + reduced PGIS <-> Enzyme-ligand complex
10-Hydroperoxyoctadeca-8,12-dienoic acid <-> Unknown + 10-Oxodec-8-enoic acid
Imidazole + PGIS <-> Enzyme-ligand complex
PGIS + 4-Phenylimidazole <-> Enzyme-ligand complex
1-Phenylimidazole + PGIS <-> Enzyme-ligand complex
PGIS + 1-Benzylimidazole <-> Enzyme-ligand complex
Clotrimazole + PGIS <-> Enzyme-ligand complex
Minoxidil + PGIS <-> Enzyme-ligand complex
Prostaglandin H2 + PGIS <-> Enzyme-ligand complex
PGIS + Sodium cyanide <-> Enzyme-ligand complex
Pyridine + PGIS <-> Enzyme-ligand complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 5.3.99.4



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