Enzyme Details

EC Classification

6.3.2.17

Enzyme name
(recommended)

tetrahydrofolate synthase

Alternative names

tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)
folylpolyglutamate synthase
folate polyglutamate synthetase
formyltetrahydropteroyldiglutamate synthetase
N10-formyltetrahydropteroyldiglutamate synthetase
folylpoly-gamma-glutamate synthase
folylpolyglutamyl synthetase
folylpoly(gamma-glutamate) synthase
folylpolyglutamate synthetase
folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
FPGS
tetrahydrofolylpolyglutamate synthase
tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
tetrahydropteroyl-[gamma-Glu]_n:L-glutamate gamma-ligase (ADP-forming)

Classification

Ligases

Forming carbon-nitrogen bonds

Acid--amino-acid ligases (peptide synthases)

Catalyses reactions

ATP + L-Glutamate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](2)

ATP + L-Glutamate + 10-Formyltetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolyl L-glutamate

ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate

ATP + L-Glutamate + Tetrahydrofolyl-[Glu](n) <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](n)

n-1 ATP + n-1 L-Glutamate + 10-Formyltetrahydrofolyl L-glutamate <-> n-1 ADP + n-1 Phosphate + 10-Formyltetrahydrofolylpolyglutamate

ATP + L-Glutamate + Tetrahydropteroyl-L-glutamate <-> ADP + Phosphate + Tetrahydropteroylpoly-gamma-diglutamate

ATP + L-Glutamate + (6R)-5,10-Methylene-5,6,7,8-tetrahydropteroyl-diglutamate <-> ADP + Phosphate + (6R)-5,10-Methylene-5,6,7,8-tetrahydropteroyl-triglutamate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 6.3.2.17