Enzyme Details

EC Classification

6.3.2.2

Enzyme name
(recommended)

glutamate---cysteine ligase

Alternative names

L-glutamate:L-cysteine gamma-ligase (ADP-forming)
gamma-glutamylcysteine synthetase
gamma-glutamyl-L-cysteine synthetase
gamma-glutamylcysteinyl synthetase

Classification

Ligases

Forming carbon-nitrogen bonds

Acid--amino-acid ligases (peptide synthases)

Catalyses reactions

ATP + L-Glutamate + L-Cysteine <-> ADP + Phosphate + gamma-L-Glutamyl-L-cysteine

ATP + N-Methyl-L-glutamate + L-alpha-Aminobutyrate <-> ADP + Phosphate + gamma-(N-Methyl-L-glutamyl)-L-alpha-aminobutyrate

ATP + L-alpha-Aminobutyrate + L-alpha-Methyl glutamate <-> ADP + Phosphate + L-alpha-Methyl-gamma-glutamyl-L-alpha-aminobutyrate

ATP + L-alpha-Aminobutyrate + L-alpha-Ethyl glutamate <-> ADP + Phosphate + L-alpha-Ethyl-gamma-glutamyl-L-alpha-aminobutyrate

ATP + L-Glutamate + S-Methyl-L-cysteine <-> ADP + Phosphate + L-gamma-Glutamyl-S-methyl-L-cysteine

ATP + L-Glutamate + O-Methylserine <-> ADP + Phosphate + L-gamma-Glutamyl-O-methylserine

ATP + L-Glutamate + 3-Cyano-L-alanine <-> ADP + Phosphate + L-gamma-Glutamyl-L-beta-cyanoalanine

ATP + L-Glutamate + L-alpha-Aminobutyrate <-> ADP + Phosphate + L-gamma-Glutamyl-L-alpha-aminobutyrate

ATP + L-Glutamate + L-allo-Threonine <-> ADP + Phosphate + L-gamma-Glutamyl-L-allo-threonine

ATP + L-Valine + L-Glutamate <-> ADP + Phosphate + L-gamma-Glutamyl-L-valine

ATP + L-Glutamate + L-Threonine <-> ADP + Phosphate + L-gamma-Glutamyl-L-threonine

ATP + L-Glutamate + L-Serine <-> ADP + Phosphate + L-gamma-Glutamyl-L-serine

ATP + L-Glutamate + L-Norvaline <-> ADP + Phosphate + L-gamma-Glutamyl-L-norvaline

ATP + L-Glutamate + L-Norleucine <-> ADP + Phosphate + L-gamma-Glutamyl-L-norleucine

ATP + L-Leucine + L-Glutamate <-> ADP + Phosphate + L-gamma-Glutamyl-L-leucine

ATP + L-Isoleucine + L-Glutamate <-> ADP + Phosphate + L-gamma-Glutamyl-L-isoleucine

ATP + L-Glutamate + L-Allylglycine <-> ADP + Phosphate + L-gamma-Glutamyl-L-allylglycine

ATP + L-Alanine + L-Glutamate <-> ADP + Phosphate + L-gamma-Glutamyl-L-alanine

ATP + Glycine + L-Glutamate <-> ADP + Phosphate + L-gamma-Glutamylglycine

ATP + L-Glutamate + 3-Chloro-L-alanine <-> ADP + Phosphate + L-gamma-Glutamyl-3-chloro-L-alanine

ATP + L-Glutamate + 3-Aminoisobutanoate <-> ADP + Phosphate + L-gamma-Glutamyl-3-aminoisobutanoate

ATP + D-Glutamate + L-alpha-Aminobutyrate <-> ADP + Phosphate + D-gamma-Glutamyl-L-alpha-aminobutyrate

ATP + S-Methyl-L-cysteine + alpha-Aminoethylglutarate <-> ADP + Phosphate + alpha-Aminoethylglutaryl-S-methyl-L-cysteine

ATP + L-Cysteine + alpha-Aminoethylglutarate <-> ADP + Phosphate + alpha-Aminoethylglutaryl-L-cysteine

ATP + L-alpha-Aminobutyrate + alpha-Aminoethylglutarate <-> ADP + Phosphate + alpha-Aminoethylglutaryl-L-alpha-aminobutyrate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 6.3.2.2