Enzyme Details

Enzyme (Recommended) Name	S-(hydroxymethyl)glutathione dehydrogenase
Alternative names	S-(hydroxymethyl)glutathione:NAD+ oxidoreductase NAD-linked formaldehyde dehydrogenase (incorrect) formaldehyde dehydrogenase (incorrect) formic dehydrogenase (incorrect) class III alcohol dehydrogenase ADH3 chi-ADH FDH (incorrect) formaldehyde dehydrogenase (glutathione) (incorrect) GS-FDH (incorrect) glutathione-dependent formaldehyde dehydrogenase (incorrect) NAD-dependent formaldehyde dehydrogenase GD-FALDH NAD- and glutathione-dependent formaldehyde dehydrogenase
EC Classification	1.1.1.284
Classification	Oxidoreductases Acting on the CH-OH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + Reduced glutathione + Formaldehyde <-> NADH + H+ + S-Formylglutathione NAD+ + Reduced glutathione + D-Lactaldehyde <-> NADH + H+ + (R)-S-Lactoylglutathione NAD+ + Ethanol <-> NADH + H+ + Acetaldehyde NAD+ + 1-Octanol <-> NADH + H+ + 1-Octanal NAD+ + 12-Hydroxydodecanoic acid <-> NADH + H+ + 12-Oxododecanoic acid NAD+ + 1-Pentanol <-> NADH + H+ + 1-Pentanal Reduced glutathione + Formaldehyde <-> S-(Hydroxymethyl)glutathione NAD+ + S-(Hydroxymethyl)glutathione <-> NADH + H+ + S-Formylglutathione NAD+ + S-(Hydroxymethyl)-8-thiooctanoate <-> NADH + H+ + S-Formyl-8-thiooctanoate NAD+ + H2O + Formaldehyde + S-Ethyl glutathione <-> NADH + H+ + Ethanol + S-Formylglutathione NAD+ + Reduced glutathione + Methylglyoxal <-> NADH + H+ + S-Pyruvylglutathione
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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