Enzyme Details

Enzyme (Recommended) Name	glucose-6-phosphate dehydrogenase
Alternative names	D-glucose-6-phosphate:NADP+ 1-oxidoreductase NADP-glucose-6-phosphate dehydrogenase Zwischenferment D-glucose 6-phosphate dehydrogenase glucose 6-phosphate dehydrogenase (NADP) NADP-dependent glucose 6-phosphate dehydrogenase 6-phosphoglucose dehydrogenase Entner-Doudoroff enzyme glucose-6-phosphate 1-dehydrogenase G6PDH GPD
EC Classification	1.1.1.49
Classification	Oxidoreductases Acting on the CH-OH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NADP+ + beta-D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone NADP+ + D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone NADP+ + Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone Glucose 6-phosphate + thio-NADP+ <-> H+ + 6-Phospho-D-glucono-1,5-lactone + thio-NADPH Glucose 6-phosphate + thio-NAD+ <-> H+ + 6-Phospho-D-glucono-1,5-lactone + thio-NADH NADP+ + D-Galactose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-galactono-1,5-lactone NADP+ + 2-Deoxy-D-glucose 6-phosphate <-> H+ + NADPH + 2-Deoxy-6-phospho-D-glucono-1,5-lactone NAD+ + Glucose 6-phosphate <-> NADH + H+ + 6-Phospho-D-glucono-1,5-lactone NAD+ + D-Glucose 6-phosphate <-> NADH + H+ + 6-Phospho-D-glucono-1,5-lactone NAD+ + D-Galactose 6-phosphate <-> NADH + H+ + 6-Phospho-D-galactono-1,5-lactone NAD+ + 2-Deoxy-D-glucose 6-phosphate <-> NADH + H+ + 2-Deoxy-6-phospho-D-glucono-1,5-lactone NADP+ + 6-Aminoglucose 6-phosphate <-> H+ + NADPH + 6-Aminoglucono-1,5-lactone NADP+ + sn-Glycerol 3-phosphate <-> Glycerone phosphate + H+ + NADPH Glucose 6-phosphate + Nicotinamide hypoxanthine dinucleotide phosphate <-> H+ + 6-Phospho-D-glucono-1,5-lactone + deamino-NADPH
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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