| Enzyme (Recommended) Name |
3alpha(or 20beta)-hydroxysteroid dehydrogenase |
| Alternative names |
3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
cortisone reductase
(R)-20-hydroxysteroid dehydrogenase
dehydrogenase, 20beta-hydroxy steroid
Delta4-3-ketosteroid hydrogenase
20beta-hydroxysteroid dehydrogenase
3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase
NADH-20beta-hydroxysteroid dehydrogenase
20beta-HSD
|
| EC Classification |
1.1.1.53
|
| Classification |
| Oxidoreductases |
| Acting on the CH-OH group of donors |
| With NAD(+) or NADP(+) as acceptor |
|
| Catalyses reactions
|
| NAD+ + Androstan-3alpha,17beta-diol <-> NADH + H+ + 5alpha-Androstane-17beta-ol-3-one |
| NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one |
| NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one |
| NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one |
| NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one |
| NAD+ + Cortolone <-> NADH + H+ + Tetrahydrocortisone |
| NAD+ + Cortol <-> NADH + H+ + Urocortisol |
| NAD+ + 3alpha,20alpha,21-Trihydroxy-5beta-pregnane-11-one <-> NADH + H+ + 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione |
| NAD+ + Pregnanediol <-> NADH + H+ + 3alpha-Hydroxy-5beta-pregnane-20-one |
| NADP+ + 7,8-Dihydrobiopterin <-> H+ + NADPH + Sepiapterin |
|
| External links
|
Expasy
KEGG
IntEnz (EBI)
IUBMB
Reactome
HepatoSys
|
|
View all entries for EC Class 1.1.1.53
|