Enzyme Details

Enzyme (Recommended) Name	3-isopropylmalate dehydrogenase
Alternative names	(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase beta-isopropylmalic enzyme beta-isopropylmalate dehydrogenase threo-Ds-3-isopropylmalate dehydrogenase 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase
EC Classification	1.1.1.85
Classification	Oxidoreductases Acting on the CH-OH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + 3-Isopropylmalate <-> NADH + H+ + 3-Carboxy-4-methyl-2-oxopentanoate NAD+ + 3-Isopropylmalate <-> NADH + H+ + CO2 + 4-Methyl-2-oxopentanoate NAD+ + 3-Ethylmalate <-> NADH + H+ + CO2 + 2-Oxopentanoate NAD+ + 3-tert-Butylmalate <-> NADH + H+ + CO2 + 2-Hydroxy-4,4-dimethylpentanoate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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