Enzyme Details

Enzyme (Recommended) Name	homoisocitrate dehydrogenase
Alternative names	(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating) 2-hydroxy-3-carboxyadipate dehydrogenase 3-carboxy-2-hydroxyadipate dehydrogenase homoisocitric dehydrogenase (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating) 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating) HICDH
EC Classification	1.1.1.87
Classification	Oxidoreductases Acting on the CH-OH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + Homoisocitrate <-> NADH + H+ + CO2 + 2-Oxoadipate Oxaloglutarate <-> CO2 + 2-Oxoadipate NAD+ + Homoisocitrate <-> NADH + H+ + Oxaloglutarate NADP+ + Mannitol <-> H+ + NADPH + D-Fructose NAD+ + Isocitrate <-> NADH + H+ + CO2 + 2-Oxoglutarate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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