Enzyme Details

Enzyme (Recommended) Name	hydroxymethylglutaryl-CoA reductase
Alternative names	(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating) beta-hydroxy-beta-methylglutaryl coenzyme A reductase beta-hydroxy-beta-methylglutaryl CoA-reductase 3-hydroxy-3-methylglutaryl coenzyme A reductase hydroxymethylglutaryl coenzyme A reductase
EC Classification	1.1.1.88
Classification	Oxidoreductases Acting on the CH-OH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	2 NAD+ + Coenzyme A + (S)-Mevalonate <-> 2 NADH + H+ + 3-Hydroxy-3-methylglutaryl-CoA NAD+ + (R)-Mevalonate <-> NADH + H+ + Mevaldate 2 NAD+ + Coenzyme A + Mevalonate <-> 2 NADH + 2 H+ + 3-Hydroxy-3-methylglutaryl-CoA NAD+ + Coenzyme A + Mevaldate <-> NADH + H+ + 3-Hydroxy-3-methylglutaryl-CoA NADH + H+ + Mevaldate <-> NAD+ + Mevalonate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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