| Enzyme (Recommended) Name |
arachidonate 12-lipoxygenase |
| Alternative names |
arachidonate:oxygen 12-oxidoreductase
Delta12-lipoxygenase
12-lipoxygenase
12Delta-lipoxygenase
C-12 lipoxygenase
12S-lipoxygenase
leukotriene A4 synthase
LTA4 synthase
|
| EC Classification |
1.13.11.31
|
| Classification |
| Oxidoreductases |
| Acting on single donors with incorporation of molecular oxygen |
| With incorporation of two atoms of oxygen |
|
| Catalyses reactions
|
| O2 + Arachidonate <-> 12-HPETE |
| O2 + Eicosapentaenoic acid <-> (5Z,8Z,10E,14Z,17Z)-(12S)-12-Hydroperoxyeicosapentaenoic acid |
| O2 + 8,11,14-Eicosatrienoate <-> (8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-8,10,14-trienoate |
| O2 + Arachidonate <-> H2O + Leukotriene A4 |
| O2 + Linoleate <-> (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate |
| 2 H2O + O2 + 2 Leukotriene A4 <-> Lipoxin |
| H2O + O2 + 5,6-EET <-> 5,6-Epoxy-12-hydroxyeicosatrienoic acid |
|
| External links
|
Expasy
KEGG
IntEnz (EBI)
IUBMB
Reactome
HepatoSys
|
|
View all entries for EC Class 1.13.11.31
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