Enzyme Details

Enzyme (Recommended) Name	nitric-oxide synthase
Alternative names	NADPH-diaphorase L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) nitric oxide synthetase endothelium-derived relaxation factor-forming enzyme endothelium-derived relaxing factor synthase NO synthase
EC Classification	1.14.13.39
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + 2 N-(omega)-Hydroxyarginine <-> NADP+ + 2 L-Citrulline + 2 Nitric oxide H+ + L-Arginine + NADPH + O2 <-> NADP+ + L-Citrulline + Nitric oxide H+ + L-Arginine + NADPH + O2 <-> H2O + NADP+ + N-(omega)-Hydroxyarginine NADH + 2 Hexacyanoferrate(III) <-> NAD+ + H+ + 2 Hexacyanoferrate(II) NADPH + 2 Hexacyanoferrate(III) <-> H+ + NADP+ + 2 Hexacyanoferrate(II)
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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