Enzyme Details

Enzyme (Recommended) Name	flavin-containing monooxygenase
Alternative names	N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming) dimethylaniline oxidase dimethylaniline N-oxidase FAD-containing monooxygenase N,N-dimethylaniline monooxygenase DMA oxidase flavin mixed function oxidase Ziegler's enzyme mixed-function amine oxidase FMO FMO-I FMO-II FMO1 FMO2 FMO3 FMO4 FMO5 flavin monooxygenase methylphenyltetrahydropyridine N-monooxygenase 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase dimethylaniline monooxygenase (N-oxide-forming)
EC Classification	1.14.13.8
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + N,N-Dimethylaniline <-> H2O + NADP+ + N,N-Dimethylaniline N-oxide H+ + NADPH + O2 + L-Selenomethionine <-> H2O + NADP+ + L-Selenomethionine selenoxide H+ + L-Methionine + NADPH + O2 <-> H2O + NADP+ + L-Methionine S-oxide H+ + NADPH + O2 + S-Benzyl-L-cysteine <-> H2O + NADP+ + S-Benzyl-L-cysteine S-oxide H+ + NADPH + O2 + Methimazole <-> H2O + NADP+ + Methimazole S-oxide H+ + NADPH + O2 + Trimethylamine <-> H2O + NADP+ + Trimethylamine N-oxide H+ + NADPH + O2 + Benzydamine <-> H2O + NADP+ + Benzydamine N-oxide NADPH + O2 + Methyl 4-tolyl sulfide <-> H2O + NADP+ + Methyl 4-tolyl sulfoxide H+ + NADPH + O2 + Ethylenethiourea <-> H2O + NADP+ + Ethylenethiourea S-oxide H+ + NADPH + O2 + Sulindac <-> H2O + NADP+ + Sulindac S-oxide
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.13.8