Enzyme Details

Enzyme (Recommended) Name	4-hydroxyacetophenone monooxygenase
Alternative names	(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) HAPMO
EC Classification	1.14.13.84
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + 4'-Hydroxyacetophenone <-> H2O + NADP+ + 4-Hydroxyphenylacetate H+ + NADPH + O2 + 4-Hydroxypropiophenone <-> H2O + NADP+ + (4-Hydroxyphenyl)propionate H+ + NADPH + O2 + 4-Aminoacetophenone <-> H2O + NADP+ + (4-Aminophenyl)acetate H+ + NADPH + O2 + 2-Hydroxyacetophenone <-> H2O + NADP+ + 2-Hydroxyphenylacetate H+ + NADPH + O2 + 3-Hydroxyacetophenone <-> H2O + NADP+ + 3-Hydroxyphenylacetate H+ + NADPH + O2 + Benzaldehyde <-> H2O + NADP+ + Benzoate H+ + NADPH + O2 + Acetophenone <-> H2O + NADP+ + Phenylacetic acid H+ + NADPH + O2 + Propiophenone <-> H2O + NADP+ + Phenyl propionate H+ + NADPH + O2 + Butyrophenone <-> H2O + NADP+ + Phenyl butyrate H+ + NADPH + O2 + Isobutyrophenone <-> H2O + NADP+ + Phenyl isobutyrate H+ + NADPH + O2 + Methylphenyl sulfide <-> H2O + NADP+ + Methyl phenyl sulfoxide H+ + NADPH + O2 + 2-Acetylpyridine <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + 4-Acetylpyridine <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + 2-Acetylpyrrole <-> H2O + NADP+ + 1H-pyrrol-2-yl acetate H+ + NADPH + O2 + 2-Pyrrole carboxaldehyde <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + Acetylcyclohexane <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + Cyclohexane carboxaldehyde <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + Hydroxyacetone <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + 3-Chloro-2-butanone <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + 2,4-Pentanedione <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + Bicyclohept-2-en-6-one <-> Unknown + H2O + NADP+ H+ + NADPH + O2 + 4-Methylacetophenone <-> H2O + NADP+ + Tolylacetate H+ + NADPH + O2 + 4-Methoxyacetophenone <-> H2O + NADP+ + 4-Methoxyphenyl acetate H+ + NADPH + O2 + 4-Fluoroacetophenone <-> H2O + NADP+ + 4-Fluorophenyl acetate H+ + NADPH + O2 + 4-Hydroxy-3-methylacetophenone <-> H2O + NADP+ + 4-Hydroxy-3-methylphenyl acetate H+ + NADPH + O2 + 4-Hydroxybenzaldehyde <-> Unknown + H2O + NADP+ NADPH + O2 + Methyl 4-tolyl sulfide <-> H2O + NADP+ + Methyl 4-tolyl sulfoxide NAD+ + 1-(4'-Hydroxyphenyl)ethanol <-> NADH + H+ + 4'-Hydroxyacetophenone
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.13.84