Enzyme Details

Enzyme (Recommended) Name	sterol 14alpha-demethylase
EC Classification	1.14.14.154
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	3 H+ + 3 NADPH + 3 O2 + Lanosterol <-> 4 H2O + 3 NADP+ + Formate + 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 3 H+ + 3 NADPH + 3 O2 + 24,25-Dihydrolanosterol <-> 4 H2O + 3 NADP+ + Formate + 4,4-Dimethyl-5alpha-cholesta-8,14-dien-3beta-ol Ketoconazole + CYP51m <-> Enzyme-inhibitor complex Itraconazole + CYP51m <-> Enzyme-inhibitor complex Fluconazole + CYP51m <-> Enzyme-inhibitor complex 3 H+ + 3 NADPH + 3 O2 + Eburicol <-> 4 H2O + 3 NADP+ + Formate + 14-Demethyleburicol 3 H+ + 3 NADPH + 3 O2 + Obtusifoliol <-> 4 H2O + 3 NADP+ + Formate + 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol Eburicol + CYP51B <-> Enzyme-ligand complex Obtusifoliol + CYP51B <-> Enzyme-ligand complex CYP51B + (R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide <-> Enzyme-inhibitor complex Voriconazole + CYP51B <-> Enzyme-inhibitor complex Lanosterol + CYP51 <-> Enzyme-ligand complex Eburicol + CYP51 <-> Enzyme-ligand complex Obtusifoliol + CYP51 <-> Enzyme-ligand complex CYP51 + 31-Norlanosterol <-> Enzyme-ligand complex CYP51 + Posaconazole <-> Enzyme-inhibitor complex CYP51 + Oteseconazole <-> Enzyme-inhibitor complex
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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