Enzyme Details

Enzyme (Recommended) Name	taxadiene 5alpha-hydroxylase
EC Classification	1.14.14.176
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	O2 + Reduced acceptor + Taxa-4(5),11(12)-diene <-> H2O + Acceptor + Taxa-4(20),11(12)-dien-5alpha-ol H+ + NADPH + O2 + Taxa-4(20),11(12)-diene <-> H2O + NADP+ + Taxa-4(20),11(12)-dien-5alpha-ol H+ + NADPH + O2 + Taxa-4(5),11(12)-diene <-> H2O + NADP+ + Taxa-4(20),11(12)-dien-5alpha-ol Taxa-4(20),11(12)-diene + Taxadiene 5alpha-hydroxylase <-> Enzyme-ligand complex Taxa-4(5),11(12)-diene + Taxadiene 5alpha-hydroxylase <-> Enzyme-ligand complex
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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