Enzyme Details

Enzyme (Recommended) Name	steroid 17alpha-monooxygenase
Alternative names	steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating) steroid 17alpha-hydroxylase cytochrome P-45017alpha cytochrome P-450 (P-45017alpha,lyase) 17alpha-hydroxylase-C17,20 lyase
EC Classification	1.14.14.19
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	O2 + Reduced acceptor + Steroid <-> H2O + Acceptor + 17-alpha-Hydroxysteroid O2 + Reduced acceptor + Progesterone <-> H2O + Acceptor + 17alpha-Hydroxyprogesterone O2 + Reduced acceptor + Pregnenolone <-> H2O + Acceptor + 17alpha-Hydroxypregnenolone H2O + Acceptor + 21-Deoxycortisol <-> O2 + Reduced acceptor + 11beta-Hydroxyprogesterone H+ + NADPH + O2 + 20alpha-Hydroxycholesterol <-> H2O + NADP+ + 17alpha,20alpha-Dihydroxycholesterol H+ + NADPH + 17alpha-Hydroxypregnenolone <-> NADP+ + 3beta-Hydroxyandrost-5-en-17-one H+ + NADPH + 17alpha-Hydroxyprogesterone <-> NADP+ + Androst-4-ene-3,17-dione H+ + NADPH + O2 + Progesterone <-> H2O + NADP+ + 17alpha-Hydroxyprogesterone H+ + NADPH + O2 + Pregnenolone <-> H2O + NADP+ + 17alpha-Hydroxypregnenolone
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.14.19