Enzyme Details

Enzyme (Recommended) Name	trans-cinnamate 4-monooxygenase
Alternative names	trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating) cinnamic acid 4-hydroxylase oxygenase, cinnamate 4-mono- CA4H cytochrome P450 cinnamate 4-hydroxylase cinnamate 4-hydroxylase cinnamate 4-monooxygenase cinnamate hydroxylase cinnamic 4-hydroxylase cinnamic acid 4-monooxygenase cinnamic acid p-hydroxylase hydroxylase, cinnamate 4- t-cinnamic acid hydroxylase trans-cinnamate 4-hydroxylase trans-cinnamic acid 4-hydroxylase
EC Classification	1.14.14.91
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 4-Coumarate H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 2-Hydroxycinnamate H+ + NADPH + O2 + 2-Fluoro-trans-cinnamate <-> H2O + NADP+ + 2-Fluoro-4-hydroxycinnamate H+ + NADPH + O2 + 2-Chloro-trans-cinnamate <-> H2O + NADP+ + 2-Chloro-4-hydroxycinnamate H+ + NADPH + O2 + 3-Hydroxycinnamate <-> H2O + NADP+ + Caffeate H+ + NADPH + O2 + 2-Methylcinnamate <-> H2O + NADP+ + 2-Methyl-4-hydroxycinnamate H+ + NADPH + O2 + 2-Ethoxycinnamate <-> H2O + NADP+ + 2-Ethoxy-4-hydroxycinnamate H+ + NADPH + O2 + 2-Methoxycinnamate <-> H2O + NADP+ + 2-Methoxy-4-hydroxycinnamate H+ + NADPH + O2 + 2-Nitrocinnamate <-> H2O + NADP+ + 2-Nitro-4-hydroxycinnamate H+ + NADPH + O2 + 2-Naphthoic acid <-> H2O + NADP+ + 6-Hydroxy-2-naphthoic acid H+ + NADPH + O2 + 2-Naphthalenesulfonic acid <-> H2O + NADP+ + 2-Naphthol-6-sulfonic acid H+ + NADPH + O2 + 1-Naphthalenesulfonic acid <-> Unknown + H2O + NADP+ trans-Cinnamate + CYP73A1 <-> Enzyme-ligand complex 2-Naphthoic acid + CYP73A1 <-> Enzyme-ligand complex 2-Hydroxy-1-naphthoic acid + CYP73A1 <-> Enzyme-inhibitor complex 1-Hydroxy-2-naphthoate + CYP73A1 <-> Enzyme-inhibitor complex CYP73A1 + 3-Hydroxy-2-naphthoic acid <-> Enzyme-inhibitor complex CYP73A1 + Indole-2-carboxylic acid <-> Enzyme-inhibitor complex 2-Naphthalenesulfonic acid + CYP73A1 <-> Enzyme-ligand complex CYP73A1 + 1-Methyl-2-naphthoic acid <-> Enzyme-inhibitor complex 1-Naphthalenesulfonic acid + CYP73A1 <-> Enzyme-ligand complex 2-Naphthaldehyde + CYP73A1 <-> Enzyme-inhibitor complex 1-Naphthoic acid + CYP73A1 <-> Enzyme-inhibitor complex 2-Quinolinecarboxylic acid + CYP73A1 <-> Enzyme-inhibitor complex Indole-3-carboxylic acid + CYP73A1 <-> Enzyme-inhibitor complex 2-Methylnaphthalene + CYP73A1 <-> Enzyme-inhibitor complex
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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