Enzyme Details

Enzyme (Recommended) Name	benzoate 4-monooxygenase
EC Classification	1.14.14.92
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + Benzoate <-> H2O + NADP+ + 4-Hydroxybenzoate H+ + NADPH + O2 + 2-Fluorobenzoate <-> H2O + NADP+ + 2-Fluoro-4-hydroxybenzoic acid H+ + NADPH + O2 + 2-Chlorobenzoate <-> H2O + NADP+ + 2-Chloro-4-hydroxybenzoic acid H+ + NADPH + O2 + Salicylate <-> H2O + NADP+ + 2,4-Dihydroxybenzoate H+ + NADPH + O2 + o-Toluate <-> H2O + NADP+ + 4-Hydroxy-2-methylbenzoic acid H+ + NADPH + O2 + 3-Fluorobenzoate <-> H2O + NADP+ + 3-Fluoro-4-hydroxybenzoic acid H+ + NADPH + O2 + 3-Chlorobenzoate <-> H2O + NADP+ + 3-Chloro-4-hydroxybenzoic acid H+ + NADPH + O2 + m-Methylbenzoate <-> H2O + NADP+ + 4-Hydroxy-3-methylbenzoic acid 3 H+ + 3 NADPH + 3 O2 + m-Methoxybenzoate <-> 4 H2O + 3 NADP+ + Formate + 3-Hydroxybenzoate Benzoate + CYP53A1 <-> Enzyme-ligand complex
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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