Enzyme Details

Enzyme (Recommended) Name leukotriene-B4 20-monooxygenase
Alternative names (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
leukotriene-B4 20-hydroxylase
leucotriene-B4 omega-hydroxylase
LTB4 20-hydroxylase
LTB4 omega-hydroxylase
EC Classification 1.14.14.94
Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Catalyses reactions
H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 20-OH-Leukotriene B4
NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 19-OH-Leukotriene B4
NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 20-OH-Leukotriene B4
H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 19-OH-Leukotriene B4
H+ + NADPH + O2 + 20-CHO-Leukotriene B4 <-> H2O + NADP+ + 20-COOH-Leukotriene B4
External links Expasy
KEGG
IntEnz (EBI)
IUBMB
Reactome
HepatoSys


View all entries for EC Class 1.14.14.94