Enzyme Details

Enzyme (Recommended) Name	calcidiol 1-monooxygenase
Alternative names	calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating) 25-hydroxycholecalciferol 1-hydroxylase 25-hydroxycholecalciferol 1?-hydroxylase 25-hydroxyvitamin D3 1?-hydroxylase 25-hydroxycholecalciferol 1-monooxygenase 1-hydroxylase-25-hydroxyvitamin D3 25-hydroxy D3-1?-hydroxylase calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating) 25-hydroxycholecalciferol 1-hydroxylase 25-hydroxycholecalciferol 1-monooxygenase 1-hydroxylase-25-hydroxyvitamin D3 25-hydroxy D3-1alpha-hydroxylase 25-hydroxycholecalciferol 1alpha-hydroxylase 25-hydroxyvitamin D3 1alpha-hydroxylase
EC Classification	1.14.15.18
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	H+ + NADPH + O2 + Calcidiol <-> H2O + NADP+ + Calcitriol H+ + NADPH + O2 + Calcidiol <-> H2O + NADP+ + Calcitriol H+ + NADPH + O2 + Secalciferol <-> H2O + NADP+ + Calcitetrol H+ + NADPH + O2 + 23S,25-Dihydroxyvitamin D3 <-> H2O + NADP+ + 1alpha,23S,25-Trihydroxyvitamin D3 H+ + NADPH + O2 + 24-Oxo-25-hydroxyvitamin D3 <-> H2O + NADP+ + 1alpha,25-Dihydroxy-24-oxovitamin D3
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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