Enzyme Details

Enzyme (Recommended) Name	steroid 11beta-monooxygenase
Alternative names	steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) steroid 11beta-hydroxylase steroid 11beta/18-hydroxylase oxygenase, steroid 11beta -mono-
EC Classification	1.14.15.4
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Catalyses reactions	O2 + Reduced ferredoxin + Progesterone <-> H2O + Oxidized ferredoxin + 11beta-Hydroxyprogesterone O2 + Reduced adrenal ferredoxin + Androst-4-ene-3,17-dione <-> H2O + Oxidized adrenal ferredoxin + 11beta-Hydroxyandrost-4-ene-3,17-dione O2 + Reduced adrenal ferredoxin + Steroid <-> H2O + Oxidized adrenal ferredoxin + 11beta-Hydroxysteroid O2 + Reduced ferredoxin + 11-Deoxycortisol <-> H2O + Oxidized ferredoxin + Cortisol H+ + NADPH + O2 + 17alpha-Hydroxyprogesterone <-> H2O + NADP+ + 21-Deoxycortisol O2 + Reduced ferredoxin + 11-Deoxycorticosterone <-> H2O + Oxidized ferredoxin + Corticosterone H+ + NADPH + O2 + 17alpha,21-Dihydroxypregnenolone <-> H2O + NADP+ + 11beta,17alpha,21-Trihydroxypregnenolone
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.15.4