Enzyme Details

Enzyme (Recommended) Name	monophenol monooxygenase
Alternative names	cresolase catechol oxidase polyphenolase phenolase catecholase monophenol,L-dopa:oxygen oxidoreductase tyrosinase monophenol oxidase pyrocatechol oxidase dopa oxidase chlorogenic oxidase polyphenol oxidase monophenolase o-diphenol oxidase chlorogenic acid oxidase diphenol oxidase o-diphenolase tyrosine-dopa oxidase o-diphenol:oxygen oxidoreductase polyaromatic oxidase monophenol monooxidase o-diphenol oxidoreductase monophenol dihydroxyphenylalanine:oxygen oxidoreductase N-acetyl-6-hydroxytryptophan oxidase monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase o-diphenol:O2 oxidoreductase phenol oxidase
EC Classification	1.14.18.1
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With another compound as one donor, and incorporation of one atom of oxygen
Catalyses reactions	2 H2O2 <-> 2 H2O + O2 O2 + 2 L-Dopa <-> 2 H2O + 2 Dopaquinone L-Tyrosine + O2 <-> H2O + L-Dopa L-Tyrosine + O2 + L-Dopa <-> H2O + L-Dopa + Dopaquinone O2 + 2 Hydroquinone <-> 2 H2O + 2 1,4-Benzoquinone NADH + H+ + O2 + Tyramine <-> NAD+ + H2O + Dopamine O2 + 4-Coumarate <-> H2O + 3,4-Dihydroxy-trans-cinnamate L-Dopachrome <-> CO2 + 5,6-Dihydroxyindole O2 + (S)-N-Methylcoclaurine <-> H2O + 3'-Hydroxy-N-methyl-(S)-coclaurine O2 + 2 5,6-Dihydroxyindole <-> 2 H2O + 2 Indole-5,6-quinone H2O2 + 4-Chlorophenol <-> H2O + 4-Chlorocatechol H2O2 + 4-Cresol <-> H2O + 4-Methylcatechol H2O2 + Methylparaben <-> H2O + Methyl 3,4-dihydroxybenzoate H2O2 + p-Bromophenol <-> H2O + 4-Bromocatechol H2O2 + p-Fluorophenol <-> H2O + 4-Fluorocatechol O2 + (+)-Catechin <-> H2O + Catechin-O-quinone O2 + L-Dopa <-> H2O + L-Dopachrome O2 + Quercetin <-> H2O + Quercetin o-quinone O2 + 4-(tert-Butyl)benzo-1,2-quinone + 4-tert-Butylcatechol <-> 2 H2O O2 + L-Noradrenaline <-> H2O2 + L-Noradrenalinequinone O2 + L-Dopa <-> H2O2 + L-Dopaquinone O2 + L-Adrenaline <-> H2O2 + L-Adrenalinequinone O2 + 2 D-Dopa <-> 2 H2O + 2 D-Dopaquinone O2 + 2 L-Dopa <-> 2 H2O + 2 L-Dopaquinone O2 + 2 L-Noradrenaline <-> 2 H2O + 2 L-Noradrenalinequinone O2 + D-Dopa <-> H2O2 + D-Dopaquinone O2 + 2 L-Adrenaline <-> 2 H2O + 2 L-Adrenalinequinone O2 + Dopaxanthin <-> 2 H2O + Dipicolinic acid O2 + Dopaxanthin <-> 2 H2O + Dopaxanthinquinone O2 + Acetaminophen <-> H2O + 4-Acetamido-o-benzoquinone O2 + 2 Catechol <-> 2 H2O + 2 1,2-Benzoquinone O2 + 2 4-Methylcatechol <-> 2 H2O + 2 4-Methyl-o-benzoquinone O2 + 2 4-tert-Butylcatechol <-> 2 H2O + 2 4-tert-Butyl-o-benzoquinone O2 + 2 3,4-Dihydroxyphenylacetate <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)acetic acid O2 + 2 3,4-Dihydroxyphenyl propionic acid <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)propionic acid O2 + 2 Dopamine <-> 2 H2O + 2 Dopamine quinone O2 + 2 L-alpha-Methyldopa <-> 2 H2O + 2 L-alpha-Methyldopaquinone O2 + 2 Dopa methyl ester <-> 2 H2O + 2 Dopaquinone methyl ester O2 + 2 Levisoprenaline <-> 2 H2O + 2 1-[1-Hydroxy-2-(propan-2-ylamino)ethyl]-3,4-dioxocyclohexa-1,5-diene O2 + 4-Hydroxyanisole <-> H2O + 3-Methoxycatechol O2 + 4-Ethoxyphenol <-> H2O + 3-Ethoxycatechol O2 + 4-Hydroxyphenyl propionic acid <-> H2O + 3,4-Dihydroxyphenyl propionic acid O2 + 4-Hydroxyphenylacetate <-> H2O + 3,4-Dihydroxyphenylacetate O2 + Tyramine <-> H2O + Dopamine O2 + Phenol <-> H2O + Catechol O2 + L-alpha-Methyltyrosine <-> H2O + L-alpha-Methyldopa 2 L-Tyrosine + O2 <-> 2 L-Dopa L-Tyrosine + O2 <-> H2O + Dopaquinone L-Tyrosine + O2 <-> H2O + L-Dopaquinone O2 + D-Tyrosine <-> H2O + D-Dopaquinone O2 + 4-Cresol <-> H2O + 4-Methylcatechol O2 + 4-tert-Butylphenol <-> H2O + 4-tert-Butylcatechol
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.18.1