Enzyme Details

Enzyme (Recommended) Name	prostaglandin-endoperoxide synthase
Alternative names	(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase prostaglandin synthase prostaglandin G/H synthase (PG)H synthase PG synthetase prostaglandin synthetase fatty acid cyclooxygenase prostaglandin endoperoxide synthetase
EC Classification	1.14.99.1
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen Miscellaneous (requires further characterization)
Catalyses reactions	O2 + 2 Prostaglandin H2 <-> 2 Prostaglandin G2 2 O2 + Arachidonate <-> Prostaglandin G2 2 O2 + Arachidonate + Reduced acceptor <-> H2O + Acceptor + Prostaglandin H2 Guaiacol + 5-Hydroperoxypent-1-enylbenzene <-> Reduced 5-hydroperoxypent-1-enylbenzene + Oxidized guaiacol 2 Guaiacol + 15-HPETE <-> H2O + 15-HETE + 3,3'-Dimethoxydipheno-4,4'-quinone 2 Guaiacol + Ethyl hydroperoxide <-> H2O + Ethanol + 3,3'-Dimethoxydipheno-4,4'-quinone H2O2 + 2 Guaiacol <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone Guaiacol + t-Butylhydroperoxide <-> H2O + t-Butanol + 3,3'-Dimethoxydipheno-4,4'-quinone 2 Guaiacol + trans-5-Phenyl-4-pentenyl hydroperoxide <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone + 5-Phenyl-4E-pentenol 2 O2 + alpha-Linolenate + Reduced acceptor <-> Unknown + H2O + Acceptor 2 O2 + Reduced acceptor + Dihomolinoleate <-> Unknown + H2O + Acceptor 2 O2 + gamma-Linolenic acid + Reduced acceptor <-> Unknown + H2O + Acceptor 2 O2 + Reduced acceptor + 8,11,14-Eicosatrienoate <-> Unknown + H2O + Acceptor 2 O2 + Eicosapentaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor 2 O2 + Reduced acceptor + Docosatetraenoic acid <-> Unknown + H2O + Acceptor 2 O2 + Docosahexaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
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