Enzyme Details

Enzyme (Recommended) Name	malonate-semialdehyde dehydrogenase (acetylating)
Alternative names	3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating) malonic semialdehyde oxidative decarboxylase
EC Classification	1.2.1.18
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + Coenzyme A + 3-Oxopropanoate <-> NADH + H+ + CO2 + Acetyl-CoA NADP+ + Coenzyme A + 3-Oxopropanoate <-> H+ + NADPH + CO2 + Acetyl-CoA NADP+ + Coenzyme A + 3-Oxopropanoate <-> H+ + NADPH + Malonyl-CoA NAD+ + Coenzyme A + (S)-Methylmalonate semialdehyde <-> NADH + H+ + (R)-2-Methyl-3-oxopropanoyl-CoA
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.1.18