Enzyme Details

Enzyme (Recommended) Name	2-oxoisovalerate dehydrogenase (acylating)
Alternative names	3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating) 2-oxoisovalerate dehydrogenase alpha-ketoisovalerate dehydrogenase
EC Classification	1.2.1.25
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + Coenzyme A + alpha-Ketovaline <-> NADH + H+ + CO2 + 2-Methylpropanoyl-CoA NAD+ + Coenzyme A + 4-Methyl-2-oxopentanoate <-> NADH + H+ + CO2 + 3-Methylbutanoyl-CoA NAD+ + Coenzyme A + 3-Methyl-2-oxopentanoate <-> NADH + H+ + CO2 + 2-Methylbutanoyl-CoA
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.1.25