Enzyme Details

Enzyme (Recommended) Name	methylmalonate-semialdehyde dehydrogenase (acylating)
Alternative names	2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating) MSDH MMSA dehydrogenase
EC Classification	1.2.1.27
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + Coenzyme A + 3-Oxopropanoate <-> NADH + H+ + CO2 + Acetyl-CoA NAD+ + Coenzyme A + 2-Methyl-3-oxopropanoate <-> NADH + H+ + CO2 + Propanoyl-CoA NAD+ + Coenzyme A + (S)-Methylmalonate semialdehyde <-> NADH + H+ + CO2 + Propanoyl-CoA NAD+ + H2O + 2-Methyl-3-oxopropanoate <-> NADH + H+ + CO2 + Propanoate NAD+ + H2O + 3-Oxopropanoate <-> NADH + H+ + CO2 + Acetate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.1.27