Enzyme Details

Enzyme (Recommended) Name	pyruvate dehydrogenase (acetyl-transferring)
Alternative names	pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) MtPDC (mitochondrial pyruvate dehydogenase complex) pyruvate decarboxylase pyruvate dehydrogenase pyruvate dehydrogenase (lipoamide) pyruvate dehydrogenase complex pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) pyruvic acid dehydrogenase pyruvic dehydrogenase
EC Classification	1.2.4.1
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With a disulfide as acceptor
Catalyses reactions	Pyruvate + Lipoamide <-> CO2 + S-Acetyldihydrolipoamide Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA Lipoamide + 2-(alpha-Hydroxyethyl)thiamine diphosphate <-> Thiamine diphosphate + S-Acetyldihydrolipoamide CO2 + 2-(alpha-Hydroxyethyl)thiamine diphosphate <-> Pyruvate + Thiamine diphosphate Pyruvate + 2,6-Dichloroindophenol <-> CO2 + Acetaldehyde + Reduced 2,6-dichlorophenolindophenol Thiamine 2-thiazolone diphosphate + PDHc E1 <-> Enzyme-inhibitor complex PDHc E1 + Thiamine 2-thiothiazolone pyrophosphate <-> Enzyme-inhibitor complex Thiamine diphosphate + PDHc E1 <-> Enzyme-ligand complex Pyruvate + H2O + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Acetate + 2 Hexacyanoferrate(II) H2O + 2-Oxobutyrate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Propanoate + 2 Hexacyanoferrate(II) H2O + 4-Methyl-2-oxopentanoate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + 2 Hexacyanoferrate(II) + Isovaleric acid
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.4.1