Enzyme Details

Enzyme (Recommended) Name	oxoglutarate dehydrogenase (succinyl-transferring)
Alternative names	2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) 2-ketoglutarate dehydrogenase 2-oxoglutarate dehydrogenase 2-oxoglutarate: lipoate oxidoreductase 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) alpha-ketoglutarate dehydrogenase alphaketoglutaric acid dehydrogenase alpha-ketoglutaric dehydrogenase alpha-oxoglutarate dehydrogenase AKGDH OGDC ketoglutaric dehydrogenase oxoglutarate decarboxylase oxoglutarate dehydrogenase oxoglutarate dehydrogenase (lipoamide)
EC Classification	1.2.4.2
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With a disulfide as acceptor
Catalyses reactions	Thiamine diphosphate + 2-Oxoglutarate <-> CO2 + 3-Carboxy-1-hydroxypropyl-ThPP Lipoamide + 3-Carboxy-1-hydroxypropyl-ThPP <-> Thiamine diphosphate + S-Succinyldihydrolipoamide Lipoamide + 2-Oxoglutarate <-> CO2 + S-Succinyldihydrolipoamide NAD+ + Coenzyme A + 2-Oxoadipate <-> NADH + H+ + CO2 + Glutaryl-CoA Lipoamide + 2-Oxoadipate <-> CO2 + S-Glutaryldihydrolipoamide NAD+ + Coenzyme A + 2-Oxoglutarate <-> NADH + H+ + CO2 + Succinyl-CoA H2O + 2-Oxoglutarate + Hexacyanoferrate(III) <-> CO2 + Succinate + Hexacyanoferrate(II) 2-Oxoglutarate + 2,6-Dichloroindophenol <-> CO2 + Succinate semialdehyde + Reduced 2,6-dichlorophenolindophenol NADP+ + Coenzyme A + 2-Oxoglutarate <-> H+ + NADPH + CO2 + Succinyl-CoA H2O + 2-Oxoglutarate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Succinate + 2 Hexacyanoferrate(II)
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.4.2