Enzyme Details

Enzyme (Recommended) Name	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
Alternative names	3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) 2-oxoisocaproate dehydrogenase 2-oxoisovalerate (lipoate) dehydrogenase 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) 3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) alpha-keto-alpha-methylvalerate dehydrogenase alpha-ketoisocaproate dehydrogenase alpha-ketoisocaproic dehydrogenase alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase alpha-ketoisovalerate dehydrogenase alpha-oxoisocaproate dehydrogenase BCKDH BCOAD branched chain keto acid dehydrogenase branched-chain (-2-oxoacid) dehydrogenase (BCD) branched-chain 2-keto acid dehydrogenase branched-chain 2-oxo acid dehydrogenase branched-chain alpha-keto acid dehydrogenase branched-chain alpha-oxo acid dehydrogenase branched-chain keto acid dehydrogenase branched-chain ketoacid dehydrogenase dehydrogenase, 2-oxoisovalerate (lipoate) dehydrogenase, branched chain alpha-keto acid
EC Classification	1.2.4.4
Classification	Oxidoreductases Acting on the aldehyde or oxo group of donors With a disulfide as acceptor
Catalyses reactions	NAD+ + Coenzyme A + alpha-Ketovaline <-> NADH + H+ + CO2 + 2-Methylpropanoyl-CoA Lipoamide + alpha-Ketovaline <-> CO2 + S-(2-Methylpropanoyl)-dihydrolipoamide Lipoamide + 4-Methyl-2-oxopentanoate <-> CO2 + S-(3-Methylbutanoyl)-dihydrolipoamide Lipoamide + 3-Methyl-2-oxopentanoate <-> CO2 + S-(2-Methylbutanoyl)-dihydrolipoamide H2O + alpha-Ketovaline + Acceptor <-> H+ + CO2 + Isobutanoate + Reduced acceptor NAD+ + Coenzyme A + 4-Methyl-2-oxopentanoate <-> NADH + H+ + CO2 + 3-Methylbutanoyl-CoA
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.2.4.4