Enzyme Details

Enzyme (Recommended) Name	dihydroorotate dehydrogenase (fumarate)
Alternative names	(S)-dihydroorotate:fumarate oxidoreductase DHOdehase (ambiguous) dihydroorotate dehydrogenase (ambiguous) dihydoorotic acid dehydrogenase (ambiguous) DHOD (ambiguous) DHODase (ambiguous) dihydroorotate oxidase, pyr4 (gene name)
EC Classification	1.3.98.1
Classification	Oxidoreductases Acting on the CH-CH group of donors With other, known, physiological acceptors
Catalyses reactions	L-Dihydroorotate + Acceptor <-> Orotate + Reduced acceptor 2 NADH + 2 H+ + O2 <-> 2 NAD+ + 2 H2O O2 + L-Dihydroorotate <-> H2O2 + Orotate Fumarate + L-Dihydroorotate <-> Succinate + Orotate L-Dihydroorotate + Decylubiquinone <-> Orotate + Decylubiquinol L-Dihydroorotate + 2,6-Dichloroindophenol <-> Orotate + Reduced 2,6-dichlorophenolindophenol L-Dihydroorotate + Menadione <-> Orotate + Menadiol L-Dihydroorotate + Nitroblue tetrazolium <-> H+ + Orotate + Reduced nitroblue tetrazolium Riboflavin-5-phosphate + L-Dihydroorotate <-> Orotate + Reduced FMN Hexacyanoferrate(III) + L-Dihydroorotate <-> Orotate + Hexacyanoferrate(II) Hexacyanoferrate(III) + Dihydro-5-azaorotic acid <-> Hexacyanoferrate(II) + 5-Azaorotic acid L-Dihydroorotate + 2,3-Dimethoxy-5-methyl-1,4-benzoquinone <-> Orotate + 2,3-Dimethoxy-5-methyl-1,4-benzoquinol
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.3.98.1