Enzyme Details

Enzyme (Recommended) Name	pyrroline-5-carboxylate reductase
Alternative names	L-proline:NAD(P)+ 5-oxidoreductase proline oxidase L-proline oxidase 1-pyrroline-5-carboxylate reductase NADPH-L-Delta1-pyrroline carboxylic acid reductase L-proline-NAD(P)+ 5-oxidoreductase
EC Classification	1.5.1.2
Classification	Oxidoreductases Acting on the CH-NH group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + L-Proline <-> NADH + H+ + (S)-1-Pyrroline-5-carboxylate L-Proline + NADP+ <-> H+ + NADPH + (S)-1-Pyrroline-5-carboxylate NAD+ + trans-4-Hydroxy-L-proline <-> NADH + H+ + L-1-Pyrroline-3-hydroxy-5-carboxylate NADP+ + trans-4-Hydroxy-L-proline <-> H+ + NADPH + L-1-Pyrroline-3-hydroxy-5-carboxylate NAD+ + Thioproline <-> NADH + H+ + 1-Thiopyrroline-5-carboxylate NADP+ + Thioproline <-> H+ + NADPH + 1-Thiopyrroline-5-carboxylate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.5.1.2