Enzyme Details

Enzyme (Recommended) Name	CoA-disulfide reductase
Alternative names	CoA:NAD(P)+ oxidoreductase CoA-disulfide reductase (NADH2) NADH2:CoA-disulfide oxidoreductase CoA:NAD+ oxidoreductase CoADR coenzyme A disulfide reductase
EC Classification	1.8.1.14
Classification	Oxidoreductases Acting on a sulfur group of donors With NAD(+) or NADP(+) as acceptor
Catalyses reactions	NAD+ + 2 Coenzyme A <-> NADH + H+ + CoA-disulfide NADP+ + 2 Coenzyme A <-> H+ + NADPH + CoA-disulfide H+ + NADPH + 3'-Dephospho-CoA-disulfide <-> NADP+ + 2 3'-Dephospho-CoA H+ + NADPH + 4,4'-Diphosphopantethine <-> NADP+ + 2 4'-Phosphopantetheine NADP+ + Coenzyme A + Reduced glutathione <-> H+ + NADPH + CoA-glutathione
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.8.1.14