Enzyme Details

Enzyme (Recommended) Name	protein-disulfide reductase (glutathione)
Alternative names	glutathione:protein-disulfide oxidoreductase glutathione-insulin transhydrogenase insulin reductase reductase, protein disulfide (glutathione) protein disulfide transhydrogenase glutathione-protein disulfide oxidoreductase protein disulfide reductase (glutathione) GSH-insulin transhydrogenase protein-disulfide interchange enzyme protein-disulfide isomerase/oxidoreductase thiol:protein-disulfide oxidoreductase thiol-protein disulphide oxidoreductase
EC Classification	1.8.4.2
Classification	Oxidoreductases Acting on a sulfur group of donors With a disulfide as acceptor
Catalyses reactions	2 Reduced glutathione + Insulin <-> Oxidized glutathione + Insulin dithiol Oxidized glutathione + Protein dithiol <-> 2 Reduced glutathione + Protein disulfide Reduced glutathione + Glutathionylated RNase A <-> Oxidized glutathione + RNase A Reduced glutathione + Glutathionylated bovine serum albumin <-> Oxidized glutathione + Bovine serum albumin Reduced glutathione + Glutathionylated 2-mercaptoethanol <-> Oxidized glutathione + 2-Mercaptoethanol 2 Reduced glutathione + Hydroxyethyl disulfide <-> Oxidized glutathione + 2 2-Mercaptoethanol H+ + NADPH + Hydroxyethyl disulfide <-> NADP+ + 2 2-Mercaptoethanol NADP+ + 2 Coenzyme A <-> H+ + NADPH + CoA-disulfide NADP+ + Coenzyme A + Reduced glutathione <-> H+ + NADPH + CoA-glutathione L-Cysteine + NADP+ + Reduced glutathione <-> H+ + NADPH + S-Glutathionyl-L-cysteine NADP+ + 2 Reduced glutathione <-> H+ + NADPH + Oxidized glutathione
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.8.4.2