Enzyme Details

Enzyme (Recommended) Name	uroporphyrinogen-III C-methyltransferase
Alternative names	S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase uroporphyrinogen methyltransferase uroporphyrinogen-III methyltransferase adenosylmethionine-uroporphyrinogen III methyltransferase S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase uroporphyrinogen-III methylase SirA CysG CobA [ambiguous - see EC 2.5.1.17] SUMT uroporphyrin-III C-methyltransferase (incorrect) S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase (incorrect)
EC Classification	2.1.1.107
Classification	Transferases Transferring one-carbon groups Methyltransferases
Catalyses reactions	2 S-Adenosyl-L-methionine + Uroporphyrinogen III <-> 2 S-Adenosyl-L-homocysteine + Precorrin 2 NAD+ + Precorrin 2 <-> NADH + H+ + Sirohydrochlorin 2 S-Adenosyl-L-methionine + Uroporphyrin III <-> 2 S-Adenosyl-L-homocysteine + Sirohydrochlorin S-Adenosyl-L-methionine + Uroporphyrinogen III <-> S-Adenosyl-L-homocysteine + Precorrin 1 S-Adenosyl-L-methionine + Heptacarboxyporphyrinogen III <-> S-Adenosyl-L-homocysteine + Methylated heptacarboxyporphyrinogen III S-Adenosyl-L-methionine + Hexacarboxyporphyrinogen III <-> S-Adenosyl-L-homocysteine + Methylated hexacarboxyporphyrinogen III S-Adenosyl-L-methionine + Pentacarboxyporphyrinogen III <-> S-Adenosyl-L-homocysteine + Methylated pentacarboxyporphyrinogen III S-Adenosyl-L-methionine + Uroporphyrinogen I <-> S-Adenosyl-L-homocysteine + Methylated uroporphyrinogen I S-Adenosyl-L-methionine + Reduced chlorin <-> S-Adenosyl-L-homocysteine + Methylated reduced chlorin
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 2.1.1.107