Enzyme Details

Enzyme (Recommended) Name	catechol O-methyltransferase
Alternative names	S-adenosyl-L-methionine:catechol O-methyltransferase COMT I COMT II S-COMT (soluble form of catechol-O-methyltransferase) MB-COMT (membrane-bound form of catechol-O-methyltransferase) catechol methyltransferase catecholamine O-methyltransferase
EC Classification	2.1.1.6
Classification	Transferases Transferring one-carbon groups Methyltransferases
Catalyses reactions	S-Adenosyl-L-methionine + Catechol <-> S-Adenosyl-L-homocysteine + Guaiacol S-Adenosyl-L-methionine + L-Noradrenaline <-> S-Adenosyl-L-homocysteine + L-Normetanephrine S-Adenosyl-L-methionine + L-Adrenaline <-> S-Adenosyl-L-homocysteine + L-Metanephrine S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <-> S-Adenosyl-L-homocysteine + Homovanillate S-Adenosyl-L-methionine + Dopamine <-> S-Adenosyl-L-homocysteine + 3-Methoxytyramine S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylethyleneglycol <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylethyleneglycol S-Adenosyl-L-methionine + 3,4-Dihydroxymandelate <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxymandelate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 2.1.1.6